Now showing items 1-5 of 5
Leptin metabolically licenses T cells for activation to link nutrition and immunity.
(J Immunol, 2014-01-01)
Immune responses are highly energy-dependent processes. Activated T cells increase glucose uptake and aerobic glycolysis to survive and function. Malnutrition and starvation limit nutrients and are associated with immune ...
Metabolic regulation of T lymphocytes.
(Annu Rev Immunol, 2013)
T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP-generating processes, whereas ...
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
(J Immunol, 2011-03-15)
Stimulated CD4(+) T lymphocytes can differentiate into effector T cell (Teff) or inducible regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff and Treg require distinct metabolic programs ...
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
(J Clin Invest, 2015-01)
Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific ...
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
(J Immunol, 2011-10-15)
T cell activation leads to engagement of cellular metabolic pathways necessary to support cell proliferation and function. However, our understanding of the signal transduction pathways that regulate metabolism and their ...