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Genome-wide expression profiles of subchondral bone in osteoarthritis.
(Arthritis Res Ther, 2013)
INTRODUCTION: The aim of this study was to evaluate, for the first time, the differences
in gene expression profiles of normal and osteoarthritic (OA) subchondral bone in
human subjects. METHODS: Following histological assessment ...
Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study.
(BMC Musculoskelet Disord, 2013-03-27)
BACKGROUND: Little is known about the relationships of circulating levels of biomarkers
of cartilage degradation with biomechanical outcomes relevant to knee osteoarthritis
(OA) or biomarker changes following non-pharmacological ...
Estimating leptospirosis incidence using hospital-based surveillance and a population-based health care utilization survey in Tanzania.
(PLoS Negl Trop Dis, 2013)
BACKGROUND: The incidence of leptospirosis, a neglected zoonotic disease, is uncertain
in Tanzania and much of sub-Saharan Africa, resulting in scarce data on which to prioritize
resources for public health interventions ...
Leptospirosis and human immunodeficiency virus co-infection among febrile inpatients in northern Tanzania.
(Vector Borne Zoonotic Dis, 2013-08)
BACKGROUND: Leptospirosis and human immunodeficiency virus (HIV) infection are prevalent
in many areas, including northern Tanzania, yet little is known about their interaction.
METHODS: We enrolled febrile inpatients at ...
Outcomes and costs of autologous stem cell mobilization with chemotherapy plus G-CSF vs G-CSF alone.
(Bone Marrow Transplant, 2013-11)
Chemotherapy plus G-CSF (C+G) and G-CSF alone are two of the most common methods used
to mobilize CD34(+) cells for autologous hematopoietic SCT (AHSCT). In order to compare
and determine the real-world outcomes and costs ...
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
(PLoS One, 2013)
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and
uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature
suggests the host's inflammatory response to the ...
Comparing actual and perceived causes of fever among community members in a low malaria transmission setting in northern Tanzania.
(Trop Med Int Health, 2013-11)
OBJECTIVE: To compare actual and perceived causes of fever in northern Tanzania. METHODS:
In a standardised survey, heads of households in 30 wards in Moshi, Tanzania, were
asked to identify the most common cause of fever ...
Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma.
(Cancer Med, 2013-04)
Patients with unresectable glioblastomas have a poor prognosis, with median survival
of 6-10 months. We conducted a phase II trial of upfront 5-day temozolomide (TMZ)
and bevacizumab (BV) in patients with newly diagnosed ...
Biomarkers to help guide management of patients with pulmonary nodules.
(Am J Respir Crit Care Med, 2013-08-15)
RATIONALE: Indeterminate pulmonary nodules are a common radiographic finding and require
further evaluation because of the concern for lung cancer. OBJECTIVES: We developed
an algorithm to assign patients to a low- or high-risk ...
Chikungunya as a cause of acute febrile illness in southern Sri Lanka.
(PLoS One, 2013)
BACKGROUND: Chikungunya virus (CHIKV) re-emerged in Sri Lanka in late 2006 after a
40-year hiatus. We sought to identify and characterize acute chikungunya infection
(CHIK) in patients presenting with acute undifferentiated ...