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Chikungunya as a cause of acute febrile illness in southern Sri Lanka.
(PLoS One, 2013)
BACKGROUND: Chikungunya virus (CHIKV) re-emerged in Sri Lanka in late 2006 after a
40-year hiatus. We sought to identify and characterize acute chikungunya infection
(CHIK) in patients presenting with acute undifferentiated ...
Estimating leptospirosis incidence using hospital-based surveillance and a population-based health care utilization survey in Tanzania.
(PLoS Negl Trop Dis, 2013)
BACKGROUND: The incidence of leptospirosis, a neglected zoonotic disease, is uncertain
in Tanzania and much of sub-Saharan Africa, resulting in scarce data on which to prioritize
resources for public health interventions ...
Genome-wide expression profiles of subchondral bone in osteoarthritis.
(Arthritis Res Ther, 2013)
INTRODUCTION: The aim of this study was to evaluate, for the first time, the differences
in gene expression profiles of normal and osteoarthritic (OA) subchondral bone in
human subjects. METHODS: Following histological assessment ...
Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study.
(BMC Musculoskelet Disord, 2013-03-27)
BACKGROUND: Little is known about the relationships of circulating levels of biomarkers
of cartilage degradation with biomechanical outcomes relevant to knee osteoarthritis
(OA) or biomarker changes following non-pharmacological ...
Biomarkers to help guide management of patients with pulmonary nodules.
(Am J Respir Crit Care Med, 2013-08-15)
RATIONALE: Indeterminate pulmonary nodules are a common radiographic finding and require
further evaluation because of the concern for lung cancer. OBJECTIVES: We developed
an algorithm to assign patients to a low- or high-risk ...
Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma.
(Cancer Med, 2013-04)
Patients with unresectable glioblastomas have a poor prognosis, with median survival
of 6-10 months. We conducted a phase II trial of upfront 5-day temozolomide (TMZ)
and bevacizumab (BV) in patients with newly diagnosed ...
MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program.
(Blood, 2013-05)
Diffuse large B-cell lymphoma (DLBCL) is stratified into prognostically favorable
germinal center B-cell (GCB)-like and unfavorable activated B-cell (ABC)-like subtypes
based on gene expression signatures. In this study, ...
MDM2 phenotypic and genotypic profiling, respective to TP53 genetic status, in diffuse large B-cell lymphoma patients treated with rituximab-CHOP immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program.
(Blood, 2013-10)
MDM2 is a key negative regulator of the tumor suppressor p53, however, the prognostic
significance of MDM2 overexpression in diffuse large B-cell lymphoma (DLBCL) has not
been defined convincingly. In a p53 genetically-defined ...
Leptospirosis and human immunodeficiency virus co-infection among febrile inpatients in northern Tanzania.
(Vector Borne Zoonotic Dis, 2013-08)
BACKGROUND: Leptospirosis and human immunodeficiency virus (HIV) infection are prevalent
in many areas, including northern Tanzania, yet little is known about their interaction.
METHODS: We enrolled febrile inpatients at ...
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
(PLoS One, 2013)
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and
uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature
suggests the host's inflammatory response to the ...