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Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents.
(Journal of the American Academy of Child and Adolescent Psychiatry, 2009-05)
OBJECTIVE:To examine the psychometric properties of diagnostic criteria for prescription
analgesic opioid use disorders (OUDs) and to identify background predictors of a latent
continuum for OUD liability. METHOD:Data were ...
A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.
(J Cell Mol Med, 2009-04)
Genes can maintain spatiotemporal expression patterns by long-range interactions between
cis-acting elements. The cystic fibrosis transmembrane conductance regulator gene
(CFTR) is expressed primarily in epithelial cells. ...
Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately
2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally
do not become detectable until 12 weeks ...
Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.
(Journal of experimental & clinical cancer research : CR, 2009-06-30)
Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these
genes are involved in tumor growth and progression including angiogenesis, dissemination,
and invasiveness, we hypothesized that ...
The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.
(BMC gastroenterology, 2009-10-16)
Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis
of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes
have been associated with risk and progression ...
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.
(Br J Cancer, 2009-12-15)
BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant
glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including
27 with glioblastoma (GBM) and 32 with grade ...
MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy.
(Cancer Res, 2009-10-01)
Loss of PTEN and activation of phosphoinositide 3-kinase are commonly observed in
advanced prostate cancer. Inhibition of mammalian target of rapamycin (mTOR), a downstream
target of phosphoinositide 3-kinase signaling, ...
The toxicology of climate change: environmental contaminants in a warming world.
(Environ Int, 2009-08)
Climate change induced by anthropogenic warming of the earth's atmosphere is a daunting
problem. This review examines one of the consequences of climate change that has only
recently attracted attention: namely, the effects ...
Common genetic variation and the control of HIV-1 in humans.
(PLoS Genet, 2009-12)
To extend the understanding of host genetic determinants of HIV-1 control, we performed
a genome-wide association study in a cohort of 2,554 infected Caucasian subjects.
The study was powered to detect common genetic variants ...