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Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

Connelly, Jessica J; Crosslin, DR; Crossman, DC; Freedman, NJ; Ginsburg, Geoffrey Steven; Goldschmidt-Clermont, PJ; Granger, CB; ... (22 authors) (PLoS Genet, 2009-01)

Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, ...

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.

Chen, JR; DeWire, SM; Kovacs, JJ; Lam, CM; Lefkowitz, Robert J; Muehlbauer, Michael J; Shukla, Arun Kumar; ... (10 authors) (J Clin Invest, 2009-05)

Nicotinic acid is one of the most effective agents for both lowering triglycerides and raising HDL. However, the side effect of cutaneous flushing severely limits patient compliance. As nicotinic acid stimulates the GPCR ...

Histone modifications within the human X centromere region.

Farr, CJ; Kopf, KS; Mravinac, B; Reeves, JW; Schueler, MG; Sullivan, Beth Ann; Sullivan, LL; ... (8 authors) (PLoS One, 2009-08-12)

Human centromeres are multi-megabase regions of highly ordered arrays of alpha satellite DNA that are separated from chromosome arms by unordered alpha satellite monomers and other repetitive elements. Complexities in assembling ...

Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin.

Annis, DS; Bae, E; Erickson, Harold Paul; Mosher, DF; Xu, J; Zhang, Q (PLoS One, 2009)

BACKGROUND: Fibronectin-null cells assemble soluble fibronectin shortly after adherence to a substrate coated with intact fibronectin but not when adherent to the cell-binding domain of fibronectin (modules (7)F3-(10)F3). ...