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Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
(J Clin Invest, 2009-05)
Nicotinic acid is one of the most effective agents for both lowering triglycerides
and raising HDL. However, the side effect of cutaneous flushing severely limits patient
compliance. As nicotinic acid stimulates the GPCR ...
Histone modifications within the human X centromere region.
(PLoS One, 2009-08-12)
Human centromeres are multi-megabase regions of highly ordered arrays of alpha satellite
DNA that are separated from chromosome arms by unordered alpha satellite monomers
and other repetitive elements. Complexities in assembling ...
Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin.
(PLoS One, 2009)
BACKGROUND: Fibronectin-null cells assemble soluble fibronectin shortly after adherence
to a substrate coated with intact fibronectin but not when adherent to the cell-binding
domain of fibronectin (modules (7)F3-(10)F3). ...