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Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.

Levesque, Marc C; Moody, M Anthony; Hwang, Kwan-Ki; Marshall, Dawn J; Whitesides, John F; Amos, Joshua D; Gurley, Thaddeus C; ... (25 authors) (PLoS Med, 2009-07-07)

BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ...

Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

Guan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tan, Dongfeng; Ajani, Jaffer A; Wei, Qingyi (Journal of experimental & clinical cancer research : CR, 2009-06-30)

Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that ...

The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

Guan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tang, Dongfeng; Ajani, Jaffer A; Wei, Qingyi (BMC gastroenterology, 2009-10-16)

Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression ...

Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.

Reardon, DA; Desjardins, A; Vredenburgh, JJ; Gururangan, S; Sampson, JH; Sathornsumetee, S; McLendon, RE; ... (13 authors) (Br J Cancer, 2009-12-15)

BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including 27 with glioblastoma (GBM) and 32 with grade ...

Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance.

Nickerson, Emma K; Hongsuwan, Maliwan; Limmathurotsakul, Direk; Wuthiekanun, Vanaporn; Shah, Krupal R; Srisomang, Pramot; Mahavanakul, Weera; ... (16 authors) (PLoS One, 2009)

BACKGROUND: Most information on invasive Staphylococcus aureus infections comes from temperate countries. There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus ...

Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

Shah, Svati H; Freedman, Neil J; Zhang, Lisheng; Crosslin, David R; Stone, David H; Haynes, Carol; Johnson, Jessica; ... (22 authors) (PLoS Genet, 2009-01)

Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, ...