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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 

Cao, L; Fermor, B; Griffin, TM; Guilak, Farshid; Huebner, JL; Kraus, Virginia Byers; Rodriguiz, Ramona M; ... (9 authors) (Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ...
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Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya. 

Akwanalo, CO; Bloomfield, Gerald; Chen, P-S; Emonyi, W; Heckbert, SR; Inui, TS; Kimaiyo, S; ... (16 authors) (PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular disease burden. The clinical profile and outcomes of AF patients with valvular heart diseases in sub-Saharan Africa (SSA) have not ...
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Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan. 

Bancroft-Wu, V; Batrachenko, A; De Bellis, MD; Langkammer, C; Li, W; Liu, C; Morey, Rajendra A; ... (11 authors) (Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and iron deposition in the brain evolve ...
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The role of lipid-related genes, aging-related processes, and environment in healthspan. 

Arbeev, Konstantin; Arbeeva, L; Culminskaya, IV; Kulminski, Alexander; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling the genetic origins of healthspan. We focus on two generations in the Framingham Heart Study, the original (FHS) and offspring (FHSO) cohorts, ...
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Amygdala-prefrontal cortex functional connectivity during threat-induced anxiety and goal distraction. 

Gold, AL; McCarthy, G; Morey, Rajendra A (Biol Psychiatry, 2015-02-15)
BACKGROUND: Anxiety produced by environmental threats can impair goal-directed processing and is associated with a range of psychiatric disorders, particularly when aversive events occur unpredictably. The prefrontal cortex ...
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Trade-offs between cancer and other diseases: do they exist and influence longevity? 

Akushevich, Igor; Akushevich, L; Arbeev, Konstantin; Arbeeva, L; Culminskaya, IV; Kulminski, Alexander; Ukraintseva, Svetlana; ... (8 authors) (Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood. For example, joint increases in cancer risk and total survival observed in many human populations and some experimental aging studies ...
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Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan. 

Arbeev, Konstantin; Arbeeva, L; Christensen, Kaare; Culminskaya, IV; Kulminski, Alexander; Province, MA; Schupf, N; ... (10 authors) (PLoS Genet, 2014-01)
Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ...
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Institutional review boards' use and understanding of certificates of confidentiality. 

Beskow, Laura M; Check, Devon K; Namey, Emily E; Dame, Lauren A; Lin, Li; Cooper, Alexandra; Weinfurt, Kevin P; ... (8 authors) (PloS one, 2012-01)
Certificates of Confidentiality, issued by agencies of the U.S. government, are regarded as an important tool for meeting ethical and legal obligations to safeguard research participants' privacy and confidentiality. By ...
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Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Himburg, Heather; Meadows, Sarah K; Muramoto, Garrett G; ... (10 authors) (PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...
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Hybrid de novo genome assembly and centromere characterization of the gray mouse lemur (Microcebus murinus). 

Larsen, Peter A; Harris, R Alan; Liu, Yue; Murali, Shwetha C; Campbell, C Ryan; Brown, Adam D; Sullivan, Beth A; ... (20 authors) (BMC biology, 2017-11-16)
The de novo assembly of repeat-rich mammalian genomes using only high-throughput short read sequencing data typically results in highly fragmented genome assemblies that limit downstream applications. Here, we present an ...
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