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An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
(Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate
cancer (CaP). We demonstrated that conditional ...
Preclinical and Coclinical Studies in Prostate Cancer.
(Cold Spring Harbor perspectives in medicine, 2018-04-02)
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably
succumb to their disease. Thus there remains a pressing need for preclinical testing
of new drugs and drug combinations for late-stage ...
Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
(The Journal of pathology, 2012-01)
Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the
prostate and oestrogen receptor (ER) α is required to mediate this response. Previous
studies utilizing tissue recombination with seminal ...
SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.
(Developmental cell, 2019-02)
Frequent SPOP mutation defines the molecular feature underlying one of seven sub-types
of human prostate cancer (PrCa). However, it remains largely elusive how SPOP functions
as a tumor suppressor in PrCa. Here, we report ...
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
(Science (New York, N.Y.), 2019-05)
Activation of tumor suppressors for the treatment of human cancer has been a long
sought, yet elusive, strategy. PTEN is a critical tumor suppressive phosphatase that
is active in its dimer configuration at the plasma membrane. ...
Loss of LDAH associated with prostate cancer and hearing loss.
(Human molecular genetics, 2018-12)
Great strides in gene discovery have been made using a multitude of methods to associate
phenotypes with genetic variants, but there still remains a substantial gap between
observed symptoms and identified genetic defects. ...
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.
(Cancer discovery, 2015-05)
UNLABELLED:The ETS family of transcription factors has been repeatedly implicated
in tumorigenesis. In prostate cancer, ETS family members, such as ERG, ETV1, ETV4,
and ETV5, are frequently overexpressed due to chromosomal ...
Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.
(The American journal of pathology, 2016-12)
Increased polyamine synthesis is known to play an important role in prostate cancer.
We aimed to explore its functional significance in prostate tumor initiation and its
link to androgen receptor (AR) signaling. For this ...
Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice.
(Asian journal of andrology, 2012-07)
Early studies suggested that estrogen receptor alpha (ERα) is involved in estrogen-mediated
imprinting effects in prostate development. We recently reported a more complete ERα
knockout (KO) mouse model via mating β-actin ...
DOK2 inhibits EGFR-mutated lung adenocarcinoma.
(PloS one, 2013-01)
Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas
and the importance of EGFR mutations for the initiation and maintenance of lung cancer
is well established from mouse models and cancer ...