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Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...
Trade-offs between cancer and other diseases: do they exist and influence longevity?
(Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood.
For example, joint increases in cancer risk and total survival observed in many human
populations and some experimental aging studies ...
Mindfulness training for smokers via web-based video instruction with phone support: a prospective observational study.
(BMC complementary and alternative medicine, 2015-03-29)
BACKGROUND:Many smokers are unable to access effective behavioral smoking cessation
therapies due to location, financial limitations, schedule, transportation issues
or other reasons. We report results from a prospective ...
Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.
(Diseases of the esophagus : official journal of the International Society for Diseases
of the Esophagus, 2018-05)
Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients
with advanced lung disease and are associated with graft dysfunction following lung
transplantation. As a result, many transplant centers ...
Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.
(Int J Dermatol, 2015-01)
Abnormal skin findings are identified in over 90% of human immunodeficiency virus
(HIV)-infected persons globally. A prospective cohort study of HIV-infected patients
with skin complaints commencing antiretroviral therapy ...
Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
(Scientific reports, 2015-01)
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway
may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1
and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...
Steps to Health employee weight management randomized control trial: short-term follow-up results.
(J Occup Environ Med, 2015-02)
OBJECTIVE: To present the short-term follow-up findings of the Steps to Health study,
a randomized trial to evaluate the effectiveness of two employee weight management
programs offered within Duke University and the Health ...
Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma.
(Cancer Epidemiol Biomarkers Prev, 2015-07)
BACKGROUND: The Notch signaling pathway is constitutively activated in human cutaneous
melanoma to promote growth and aggressive metastatic potential of primary melanoma
cells. Therefore, genetic variants in Notch pathway ...
Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.
(Int J Cancer, 2015-11-15)
Single nucleotide polymorphisms (SNPs) in the promoter region of FAS and FASLG may
alter their transcriptional activity. Thus, we determined the associations between
four FAS and FASLG promoter variants (FAS1377G>A, rs2234767; ...