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Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.
(Mech Ageing Dev, 2011-04)
Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring
of older fathers. Longer telomeres might increase cancer risk. We examined the relation
of father's age at the birth of the offspring ...
Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.
(Mech Ageing Dev, 2010-05)
The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic
receptor (ADRB2) gene appears to be associated with a broad range of aging-associated
phenotypes, including cancers at different sites, ...
Trade-offs between cancer and other diseases: do they exist and influence longevity?
(Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood.
For example, joint increases in cancer risk and total survival observed in many human
populations and some experimental aging studies ...
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.
(Rejuvenation Res, 2015-04)
The lack of evolutionary established mechanisms linking genes to age-related traits
makes the problem of genetic susceptibility to health span inherently complex. One
complicating factor is genetic trade-off. Here we focused ...
Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps.
(Int J Cancer, 2012-07-15)
High levels of circulating insulin-like growth factor-1 (IGF-1) have been associated
with increased risk of several cancers. Regarding colorectal cancer, these associations
are generally weak. We hypothesized that an increase ...
The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...
Age trajectories of physiological indices in relation to healthy life course.
(Mech Ageing Dev, 2011-03)
We analysed relationship between the risk of onset of "unhealthy life" (defined as
the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes
in body mass index, diastolic blood pressure, hematocrit, ...
Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction.
(Rejuvenation Res, 2010-02)
Multiple functions of the beta2-adrenergic receptor (ADRB2) and angiotensin-converting
enzyme (ACE) genes warrant studies of their associations with aging-related phenotypes.
We focus on multimarker analyses and analyses ...
Quantification of biological aging in young adults.
(Proc Natl Acad Sci U S A, 2015-07-28)
Antiaging therapies show promise in model organism research. Translation to humans
is needed to address the challenges of an aging global population. Interventions to
slow human aging will need to be applied to still-young ...
Trade-offs between cancer and other diseases: do they exist and influence longevity?
(Rejuvenation Res, 2010-08)
Relationships between aging, disease risks, and longevity are not yet well understood.
For example, joint increases in cancer risk and total survival observed in many human
populations and some experimental aging studies ...