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Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium.
(Scientific reports, 2017-04-11)
The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events
mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway
are associated with lung cancer risk and survival. ...
Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.
(The Journal of investigative dermatology, 2015-02)
Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway
involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using
data derived from published genome-wide association ...
Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.
(International journal of cancer, 2019-02-08)
Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular
signaling processes and thus may be involved in cancer development and progression.
In the present study, we comprehensively ...
Genetic Variants in RUNX3, AMD1 and MSRA in the Methionine Metabolic Pathway and Survival in Non-small Cell Lung Cancer Patients.
(International journal of cancer, 2019-01-16)
Abnormal methionine dependence in cancer cells has led to methionine restriction as
a potential therapeutic strategy. We hypothesized that genetic variants involved in
methionine-metabolic genes are associated with survival ...
Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival.
(Carcinogenesis, 2018-07)
Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with
variation in outcomes only partially predicted by grade and stage. Additional tools
to distinguish indolent from aggressive disease are needed. ...
Potential Functional Variants in SMC2 and TP53 in the AURORA Pathway Genes and Risk of Pancreatic Cancer.
(Carcinogenesis, 2019-02-22)
The AURORA pathway participates in mitosis and cell division, and alterations in mitosis
and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA
pathway genes may be associated with susceptibility ...
Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
(Molecular carcinogenesis, 2018-01)
Metzincins are key molecules in the degradation of the extracellular matrix and play
an important role in cellular processes such as cell migration, adhesion, and cell
fusion of malignant tumors, including cutaneous melanoma ...
A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.
(PloS one, 2012-01-17)
The functional polymorphism (rs1800566) in the NQO1 gene, a 609C>T substitution, leading
to proline-to-serine amino-acid and enzyme activity changes, has been implicated in
cancer risk, but individually published studies ...
Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival.
(Carcinogenesis, 2018-12-29)
Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark
of cancer including cutaneous melanoma (CM). In the present study, using data from
a published genome-wide association study (GWAS) from ...
Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.
(International journal of cancer, 2019-04)
The complement system plays an important role in the innate and adaptive immunity,
complement components mediate tumor cytolysis of antibody-based immunotherapy, and
complement activation in the tumor microenvironment may ...