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Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.
(International journal of cancer, 2019-02-08)
Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular
signaling processes and thus may be involved in cancer development and progression.
In the present study, we comprehensively ...
Genetic Variants in RUNX3, AMD1 and MSRA in the Methionine Metabolic Pathway and Survival in Non-small Cell Lung Cancer Patients.
(International journal of cancer, 2019-01-16)
Abnormal methionine dependence in cancer cells has led to methionine restriction as
a potential therapeutic strategy. We hypothesized that genetic variants involved in
methionine-metabolic genes are associated with survival ...
Potential Functional Variants in SMC2 and TP53 in the AURORA Pathway Genes and Risk of Pancreatic Cancer.
(Carcinogenesis, 2019-02-22)
The AURORA pathway participates in mitosis and cell division, and alterations in mitosis
and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA
pathway genes may be associated with susceptibility ...
A Paper-Like Inorganic Thermal Interface Material Composed of Hierarchically Structured Graphene/Silicon Carbide Nanorods.
(ACS nano, 2019-02-13)
With the increasing integration of devices in electronics fabrication, there are growing
demands for thermal interface materials (TIMs) with high through-plane thermal conductivity
for efficiently solving thermal management ...
Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.
(International journal of cancer, 2019-04)
The complement system plays an important role in the innate and adaptive immunity,
complement components mediate tumor cytolysis of antibody-based immunotherapy, and
complement activation in the tumor microenvironment may ...
Functional variant of MTOR rs2536 and survival of Chinese gastric cancer patients.
(International journal of cancer, 2019-01)
We previously reported that some single nucleotide polymorphisms (SNPs) of candidate
genes involved in the MTOR complex1 (MTORC1) were associated with risk of gastric
cancer (GCa). In the present study, we further evaluated ...
Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.
(Cancer science, 2019-06)
Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic
PanC is often present at the time of diagnosis. Although several high- and low-penetrance
genes have been implicated in PanC, their roles ...
Genetic variants of genes in the NER pathway associated with risk of breast cancer: A large-scale analysis of 14 published GWAS datasets in the DRIVE study.
(International journal of cancer, 2019-09)
A recent hypothesis-free pathway-level analysis of genome-wide association study (GWAS)
datasets suggested that the overall genetic variation measured by single nucleotide
polymorphisms (SNPs) in the nucleotide excision ...
Lymphocyte Telomere Length Predicts Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy.
(Carcinogenesis, 2019-02-05)
Since lymphocyte telomere length (LTL) plays critical roles in the maintenance of
genomic stability and integrity, LTL thus may influence the etiology and prognosis
of squamous cell carcinoma of the oropharynx (SCCOP). However, ...
Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
(Gynecologic oncology, 2019-03-19)
OBJECTIVE:Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC)
have focused largely on populations of European ancestry. We aimed to identify common
germline variants associated with EOC risk in Asian ...