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Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.

Allgood, S; Amos, JD; Cohen, MS; Eron, JJ; Goepfert, Paul A; Gurley, TC; Haynes, Barton Ford; ... (25 authors) (PLoS Med, 2009-07-07)

BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ...

Common genetic variation and the control of HIV-1 in humans.

Antonarakis, SE; Beckmann, JS; Carrington, Mary; Castagna, A; Cirulli Rogers, Elizabeth T; Colombo, S; Cozzi-Lepri, A; ... (38 authors) (PLoS Genet, 2009-12)

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants ...