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Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
(PLoS One, 2015)
BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting
that respiratory viral infection may induce biologic pathways that contribute to MI.
We tested the hypotheses that 1) a validated ...
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)
Acute respiratory infections caused by bacterial or viral pathogens are among the
most common reasons for seeking medical care. Despite improvements in pathogen-based
diagnostics, most patients receive inappropriate antibiotics. ...
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
(PLoS One, 2013)
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and
uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature
suggests the host's inflammatory response to the ...
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)
There is great potential for host-based gene expression analysis to impact the early
diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted
the challenges and limitations of traditional ...
Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.
(PLoS Genet, 2011-08)
Exposure to influenza viruses is necessary, but not sufficient, for healthy human
hosts to develop symptomatic illness. The host response is an important determinant
of disease progression. In order to delineate host molecular ...