Now showing items 1-10 of 155
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
(Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). We demonstrated that conditional ...
Preclinical and Coclinical Studies in Prostate Cancer.
(Cold Spring Harbor perspectives in medicine, 2018-04-02)
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage ...
Corticobasal syndrome in a man with Gaucher disease type 1: Expansion of the understanding of the neurological spectrum.
(Molecular Genetics and Metabolism Reports, 2018-12)
Gaucher disease (GD) is an autosomal recessive condition that results from a deficiency of the enzyme β-glucocerebrosidase. The increased risk of primary parkinsonism symptoms among individuals affected with GD and carriers ...
American Association of Physicists in Medicine Task Group 263: Standardizing Nomenclatures in Radiation Oncology.
(International journal of radiation oncology, biology, physics, 2018-03)
A substantial barrier to the single- and multi-institutional aggregation of data to supporting clinical trials, practice quality improvement efforts, and development of big data analytics resource systems is the lack of ...
Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.
(Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2018-05)
Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients with advanced lung disease and are associated with graft dysfunction following lung transplantation. As a result, many transplant centers ...
Neural responses to emotional involuntary memories in posttraumatic stress disorder: Differences in timing and activity.
(NeuroImage. Clinical, 2018-01)
Background:Involuntary memories are a hallmark symptom of posttraumatic stress disorder (PTSD), but studies of the neural basis of involuntary memory retrieval in posttraumatic stress disorder (PTSD) are sparse. The study ...
Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.
(Arthritis research & therapy, 2018-06-14)
BACKGROUND:Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased ...
Metabolic Changes with Base-Loading in CKD.
(Clinical journal of the American Society of Nephrology : CJASN, 2018-06-22)
Utility of Autopsy among Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: One Last Chance to Learn?
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2018-06-09)
Autopsy may confirm clinical diagnoses or identify conditions that were not suspected prior to a patient's death. Previous studies evaluating the utility of autopsy in hematopoietic stem cell transplant (HSCT) recipients ...
Investigating pathogen burden in relation to a cumulative deficits index in a representative sample of US adults.
(Epidemiology and infection, 2018-06-14)
Pathogen burden is a construct developed to assess the cumulative effects of multiple, persistent pathogens on morbidity and mortality. Despite the likely biological wear and tear on multiple body systems caused by persistent ...