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Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya.
(PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular
disease burden. The clinical profile and outcomes of AF patients with valvular heart
diseases in sub-Saharan Africa (SSA) have not ...
Rationale and Design of the Lung Cancer Screening Implementation. Evaluation of Patient-Centered Care Study.
(Annals of the American Thoracic Society, 2017-10)
Screening for lung cancer using low-dose computed tomography has been demonstrated
to reduce lung cancer-related mortality and is being widely implemented. Further research
in this area is needed to assess the impact of ...
The Digital Drag and Drop Pillbox: Design and Feasibility of a Skill-based Education Model to Improve Medication Management.
(The Journal of cardiovascular nursing, 2017-09)
We present the design and feasibility testing for the "Digital Drag and Drop Pillbox"
(D-3 Pillbox), a skill-based educational approach that engages patients and providers,
measures performance, and generates reports of ...
Contribution of urinary tract infection to the burden of febrile illnesses in young children in rural Kenya.
(PLoS One, 2017)
INTRODUCTION: The clinical features of UTI in young children may not localize to the
urinary tract and closely resemble other febrile illnesses. In malaria endemic areas,
a child presenting with fever is often treated ...
Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function.
(J Am Soc Nephrol, 2017-10)
Efficacy of statin-based therapies in reducing cardiovascular mortality in individuals
with CKD seems to diminish as eGFR declines. The strongest evidence supporting the
cardiovascular benefit of statins in individuals with ...
Risk Factors for Heart Failure in Patients With Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study.
(Journal of the American Heart Association, 2017-05-17)
BACKGROUND:Heart failure is common in patients with chronic kidney disease. We studied
risk factors for incident heart failure among 3557 participants in the CRIC (Chronic
Renal Insufficiency Cohort) Study. METHODS ...
A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma.
(Cancer research, 2017-01)
LKB1 is a commonly mutated tumor suppressor in non-small cell lung cancer that exerts
complex effects on signal transduction and transcriptional regulation. To better understand
the downstream impact of loss of functional ...
Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.
(PloS one, 2017-01)
Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage
matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum
levels of type IIA procollagen amino terminal propeptide ...
Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.
(Science signaling, 2017-05-16)
Placental activation of the renin-angiotensin system (RAS) plays a key role in the
pathogenesis of preeclampsia. Reactive oxygen species (ROS) are thought to affect
placental angiogenesis, which is critical for preventing ...
Human Papillomavirus Awareness in Haiti: Preparing for a National HPV Vaccination Program.
(J Pediatr Adolesc Gynecol, 2017-02)
STUDY OBJECTIVE: Cervical cancer morbidity and mortality are pressing public health
issues that affect women in Haiti. To inform efforts to develop a human papillomavirus
(HPV) vaccination program in Haiti, we sought to ...