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Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.
(Circulation, 2001-03-06)
BACKGROUND: Genetic manipulation to reverse molecular abnormalities associated with
dysfunctional myocardium may provide novel treatment. This study aimed to determine
the feasibility and functional consequences of in vivo ...
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
(Mol Cell Biol, 2004-10)
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization
and desensitization of G-protein-coupled receptors (GPCRs) and also participates in
the process of heterologous desensitization between ...
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
(Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein
kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide
regulatory protein (G(s)) to inhibitory guanine nucleotide ...
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
(Proc Natl Acad Sci U S A, 2000-02-01)
Recently, we identified a GTPase-activating protein for the ADP ribosylation factor
family of small GTP-binding proteins that we call GIT1. This protein initially was
identified as an interacting partner for the G protein-coupled ...
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
(Proc Natl Acad Sci U S A, 2000-02-15)
Acting through a number of distinct pathways, many G protein-coupled receptors (GPCRs)
activate the extracellular signal-regulated kinase (ERK)/mitogen-activated protein
kinase (MAPK) cascade. Recently, it has been shown ...
Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
(Circ Res, 2000-01-07)
G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled
receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization.
In vivo analysis of GRK substrate selectivity has ...
The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy.
(J Clin Invest, 2007-12)
The clinical utility of anthracycline anticancer agents, especially doxorubicin, is
limited by a progressive toxic cardiomyopathy linked to mitochondrial damage and cardiomyocyte
apoptosis. Here we demonstrate that ...
Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.
(Br J Cancer, 2006-10-23)
Elevated intratumoral interstitial fluid pressure (IFP) and tumour hypoxia are independent
predictive factors for poor survival and poor treatment response in cancer patients.
However, the relationship between IFP and tumour ...
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
(Proc Natl Acad Sci U S A, 2001-02-27)
Using both confocal immunofluorescence microscopy and biochemical approaches, we have
examined the role of beta-arrestins in the activation and targeting of extracellular
signal-regulated kinase 2 (ERK2) following stimulation ...