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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. 

Luttrell, LM; Roudabush, FL; Choy, EW; Miller, WE; Field, ME; Pierce, KL; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 2001-02-27)
Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the activation and targeting of extracellular signal-regulated kinase 2 (ERK2) following stimulation ...
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Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 

Pierce, KL; Maudsley, S; Daaka, Y; Luttrell, LM; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 2000-02-15)
Acting through a number of distinct pathways, many G protein-coupled receptors (GPCRs) activate the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) cascade. Recently, it has been shown ...
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Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. 

Maudsley, S; Zamah, AM; Rahman, N; Blitzer, JT; Luttrell, LM; Lefkowitz, RJ; Hall, RA (Mol Cell Biol, 2000-11)
Platelet-derived growth factor (PDGF) is a potent mitogen for many cell types. The PDGF receptor (PDGFR) is a receptor tyrosine kinase that mediates the mitogenic effects of PDGF by binding to and/or phosphorylating a variety ...

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AuthorLefkowitz, RJ (3)
Luttrell, LM (3)
Maudsley, S (2)Pierce, KL (2)Blitzer, JT (1)Choy, EW (1)Daaka, Y (1)Field, ME (1)Hall, RA (1)Miller, WE (1)... View MoreDate Issued2000 (2)2001 (1)TypeJournal article (3)Subject
Animals (3)
Mitogen-Activated Protein Kinases (2)Phosphorylation (2)Adrenergic alpha-Agonists (1)Amino Acid Motifs (1)Angiotensin II (1)Arrestins (1)beta-Arrestin 2 (1)beta-Arrestins (1)Brimonidine Tartrate (1)... View MoreAffiliation of Duke Author(s)Basic Science Departments (3)Biochemistry (3)Chemistry (3)
Clinical Science Departments (3)
Duke (3)Duke Cancer Institute (3)
Institutes and Centers (3)
Medicine (3)
Medicine, Cardiology (3)Pathology (3)... View More
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