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Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 

Bohn, Laura M; Lefkowitz, Robert J; Caron, Marc G (J Neurosci, 2002-12-01)
Morphine induces antinociception by activating mu opioid receptors (muORs) in spinal and supraspinal regions of the CNS. (Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in ...
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Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 

Fong, Alan M; Premont, Richard T; Richardson, Ricardo M; Yu, Yen-Rei A; Lefkowitz, Robert J; Patel, Dhavalkumar D (Proc Natl Acad Sci U S A, 2002-05-28)
Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium and is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting ...
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Regulation of G protein-coupled receptor signaling by scaffold proteins. 

Hall, Randy A; Lefkowitz, Robert J (Circ Res, 2002-10-18)
The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric ...

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AuthorLefkowitz, Robert J (3)Bohn, Laura M (1)Caron, Marc G (1)Fong, Alan M (1)Hall, Randy A (1)Patel, Dhavalkumar D (1)Premont, Richard T (1)Richardson, Ricardo M (1)Yu, Yen-Rei A (1)Date Issued
2002 (3)
TypeJournal article (3)Subject
Animals (3)
Arrestins (3)beta-Arrestins (3)Mice (2)Mice, Knockout (2)Alkaloids (1)Analgesics, Opioid (1)Benzophenanthridines (1)beta-Arrestin 2 (1)Binding, Competitive (1)... View MoreAffiliation of Duke Author(s)Basic Science Departments (3)Biochemistry (3)Chemistry (3)
Clinical Science Departments (3)
Duke (3)Duke Cancer Institute (3)
Institutes and Centers (3)
Medicine (3)
Medicine, Cardiology (3)Pathology (3)... View More
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