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beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. 

Huang, J; Hupfeld, CJ; Imamura, T; Lefkowitz, Robert J; Olefsky, JM; Satoh, H; Shenoy, SK; ... (8 authors) (Mol Cell Biol, 2004-10)
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between ...
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Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 

Bohn, Laura M; Gainetdinov, Raul R; Sotnikova, Tatyana D; Medvedev, Ivan O; Lefkowitz, Robert J; Dykstra, Linda A; Caron, Marc G (J Neurosci, 2003-11-12)
The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ...
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Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 

Bohn, Laura M; Lefkowitz, Robert J; Caron, Marc G (J Neurosci, 2002-12-01)
Morphine induces antinociception by activating mu opioid receptors (muORs) in spinal and supraspinal regions of the CNS. (Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in ...
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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. 

Wei, Huijun; Ahn, Seungkirl; Shenoy, Sudha K; Karnik, Sadashiva S; Hunyady, László; Luttrell, Louis M; Lefkowitz, Robert J (Proc Natl Acad Sci U S A, 2003-09-16)
Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II) or of a wild-type receptor with an Ang II analog ([sarcosine1,Ile4,Ile8]Ang II) fails to activate classical heterotrimeric G protein ...
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Beta-arrestin-2 regulates the development of allergic asthma. 

Walker, Julia KL; Fong, Alan M; Lawson, Barbara L; Savov, Jordan D; Patel, Dhavalkumar D; Schwartz, David A; Lefkowitz, Robert J (J Clin Invest, 2003-08)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function ...
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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. 

Noma, Takahisa; Lemaire, Anthony; Naga Prasad, Sathyamangla V; Barki-Harrington, Liza; Tilley, Douglas G; Chen, Juhsien; Le Corvoisier, Philippe; ... (11 authors) (J Clin Invest, 2007-09)
Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl ...

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. 

Meloni, Alison R; Fralish, Gregory B; Kelly, Patrick; Salahpour, Ali; Chen, James K; Wechsler-Reya, Robert J; Lefkowitz, Robert J; ... (8 authors) (Mol Cell Biol, 2006-10)
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation ...
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Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 

Fong, Alan M; Premont, Richard T; Richardson, Ricardo M; Yu, Yen-Rei A; Lefkowitz, Robert J; Patel, Dhavalkumar D (Proc Natl Acad Sci U S A, 2002-05-28)
Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium and is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting ...
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Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. 

Kim, Jihee; Zhang, Lisheng; Peppel, Karsten; Wu, Jiao-Hui; Zidar, David A; Brian, Leigh; DeWire, Scott M; ... (10 authors) (Circ Res, 2008-07-03)
Atherosclerosis and arterial injury-induced neointimal hyperplasia involve medial smooth muscle cell (SMC) proliferation and migration into the arterial intima. Because many 7-transmembrane and growth factor receptors promote ...
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beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. 

Chen, W; Hu, LA; Semenov, MV; Yanagawa, S; Kikuchi, A; Lefkowitz, RJ; Miller, WE (Proc Natl Acad Sci U S A, 2001-12-18)
One aspect of the function of the beta-arrestins is to serve as scaffold or adapter molecules coupling G-protein coupled receptors (GPCRs) to signal transduction pathways distinct from traditional second messenger pathways. ...
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AuthorLefkowitz, Robert J (11)Caron, Marc G (3)Lefkowitz, RJ (3)Bohn, Laura M (2)DeWire, Scott M (2)Fong, Alan M (2)Miller, WE (2)Patel, Dhavalkumar D (2)Violin, Jonathan D (2)Wei, Huijun (2)... View MoreDate Issued2003 (4)2001 (3)2002 (3)2004 (1)2006 (1)2007 (1)2008 (1)2009 (1)TypeJournal article (15)Subject
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beta-Arrestins (15)Mice (10)Humans (9)beta-Arrestin 2 (7)Cell Line (7)Mice, Knockout (6)Signal Transduction (6)Phosphorylation (5)... View MoreAffiliation of Duke Author(s)Basic Science Departments (15)Biochemistry (15)Chemistry (15)
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