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Hypertension and obesity as cardiovascular risk factors among HIV seropositive patients in Western Kenya.
(PLoS One, 2011)
BACKGROUND: There is increased risk of cardiovascular disease among HIV seropositive
individuals. The prevalence of HIV is highest in sub-Saharan Africa; however, HIV-related
cardiovascular risk research is largely derived ...
Downstream coronary effects of drug-eluting stents.
(Am Heart J, 2011-10)
BACKGROUND: Antiproliferative agents used in drug-eluting stents (DES) attenuate atherosclerosis,
yet DES implantation has been linked to endothelial dysfunction. The downstream effects
of DES on new lesion formation have ...
The effect of gemfibrozil, niacin and cholestyramine combination therapy on metabolic syndrome in the Armed Forces Regression Study.
(Am J Med Sci, 2011-05)
INTRODUCTION: Metabolic syndrome is a powerful predictor of cardiovascular events
independent of overt diabetes. Dietary restriction and weight loss modify metabolic
syndrome components. This study addresses whether combination ...
Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.
(Diabetes Care, 2011-01)
OBJECTIVE: To understand relationships between exercise training-mediated improvements
in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic
intermediates, hormones, and inflammatory mediators. ...
Association of anemia and long-term survival in patients with pulmonary hypertension.
(Int J Cardiol, 2011-08-04)
BACKGROUND: Anemia is a marker of worsened clinical outcome in patients with heart
failure from left ventricular dysfunction. Pulmonary hypertension often results in
right ventricular dysfunction. Accordingly we sought to ...
Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients.
(BMC Med Genomics, 2011-03-28)
BACKGROUND: Alterations in gene expression in peripheral blood cells have been shown
to be sensitive to the presence and extent of coronary artery disease (CAD). A non-invasive
blood test that could reliably assess obstructive ...
Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.
(PLoS Genet, 2011-08)
Exposure to influenza viruses is necessary, but not sufficient, for healthy human
hosts to develop symptomatic illness. The host response is an important determinant
of disease progression. In order to delineate host molecular ...
Long-term outcome and impact of surgery on adults with coronary arteries originating from the opposite coronary cusp.
(Circulation, 2011-01-18)
BACKGROUND: An anomalous coronary artery from the opposite sinus of Valsalva may increase
sudden death risk in children and young adults, and surgical intervention is often
recommended. The impact of this lesion when recognized ...
Association between stroke center hospitalization for acute ischemic stroke and mortality.
(JAMA, 2011-01)
Although stroke centers are widely accepted and supported, little is known about their
effect on patient outcomes.To examine the association between admission to stroke
centers for acute ischemic stroke and mortality.Obs...
Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system.
(BMC Health Serv Res, 2011-10-11)
BACKGROUND: The CDC's Family History Public Health Initiative encourages adoption
and increase awareness of family health history. To meet these goals and develop a
personalized medicine implementation science research agenda, ...