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    beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. 

    Huang, J; Hupfeld, CJ; Imamura, T; Lefkowitz, Robert J; Olefsky, JM; Satoh, H; Shenoy, SK; ... (8 authors) (Mol Cell Biol, 2004-10)
    beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between ...
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    beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 

    Baillie, GS; Gall, I; Houslay, MD; Lefkowitz, Robert J; McPhee, I; Perry, SJ; Sood, A (Proc Natl Acad Sci U S A, 2003-02-04)
    Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide regulatory protein (G(s)) to inhibitory guanine nucleotide ...
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    Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. 

    Choy, EW; Field, ME; Lefkowitz, Robert J; Luttrell, LM; Miller, WE; Pierce, KL; Roudabush, FL (Proc Natl Acad Sci U S A, 2001-02-27)
    Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the activation and targeting of extracellular signal-regulated kinase 2 (ERK2) following stimulation ...
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    Regulation of G protein-coupled receptor signaling by scaffold proteins. 

    Hall, RA; Lefkowitz, Robert J (Circ Res, 2002-10-18)
    The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric ...
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    beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 

    Chen, JR; DeWire, SM; Kovacs, JJ; Lam, CM; Lefkowitz, Robert J; Muehlbauer, Michael J; Shukla, Arun Kumar; ... (10 authors) (J Clin Invest, 2009-05)
    Nicotinic acid is one of the most effective agents for both lowering triglycerides and raising HDL. However, the side effect of cutaneous flushing severely limits patient compliance. As nicotinic acid stimulates the GPCR ...
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    Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 

    Bohn, LM; Caron, MG; Lefkowitz, Robert J (J Neurosci, 2002-12-01)
    Morphine induces antinociception by activating mu opioid receptors (muORs) in spinal and supraspinal regions of the CNS. (Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in ...
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    Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 

    Bohn, LM; Caron, MG; Dykstra, LA; Gainetdinov, RR; Lefkowitz, Robert J; Medvedev, IO; Sotnikova, TD (J Neurosci, 2003-11-12)
    The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ...
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    Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. 

    Barki-Harrington, L; Chen, J; Le Corvoisier, P; Lefkowitz, Robert J; Lemaire, A; Naga Prasad, SV; Noma, T; ... (11 authors) (J Clin Invest, 2007-09)
    Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl ...
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    Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. 

    Ahn, S; Hunyady, L; Karnik, SS; Lefkowitz, Robert J; Luttrell, LM; Shenoy, SK; Wei, H (Proc Natl Acad Sci U S A, 2003-09-16)
    Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II) or of a wild-type receptor with an Ang II analog ([sarcosine1,Ile4,Ile8]Ang II) fails to activate classical heterotrimeric G protein ...
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    Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. 

    Ahn, S; Garrison, TR; Lefkowitz, Robert J; Miller, WE; Nelson, CD (Proc Natl Acad Sci U S A, 2003-02-18)
    Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a ...
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    Lefkowitz, Robert J (16)
    Caron, MG (3)Miller, WE (3)Ahn, S (2)Bohn, LM (2)DeWire, SM (2)Fong, AM (2)Luttrell, LM (2)Patel, DD (2)Perry, SJ (2)... View MoreDate Issued2003 (5)2001 (3)2002 (3)2004 (1)2006 (1)2007 (1)2008 (1)2009 (1)TypeJournal article (16)Subject
    Arrestins (16)
    beta-Arrestins (16)Animals (15)Humans (10)Mice (10)Cell Line (8)beta-Arrestin 2 (7)Signal Transduction (7)Mice, Knockout (6)Phosphorylation (6)... View MoreAffiliation of Duke Author(s)Basic Science Departments (16)Biochemistry (16)Chemistry (16)
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    Institutes and Centers (16)Medicine (16)Medicine, Cardiology (16)Pathology (16)... View More