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Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.
(Transplantation, 2015-12)
BACKGROUND: Blocking leukocyte function-associated antigen (LFA)-1 in organ transplant
recipients prolongs allograft survival. However, the precise mechanisms underlying
the therapeutic potential of LFA-1 blockade in preventing ...
Snap-shot multispectral imaging of vascular dynamics in a mouse window-chamber model.
(Opt Lett, 2015-07-15)
Understanding tumor vascular dynamics through parameters such as blood flow and oxygenation
can yield insight into tumor biology and therapeutic response. Hyperspectral microscopy
enables optical detection of hemoglobin ...
CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections.
(Dis Model Mech, 2015-12)
Visualization of infection and the associated host response has been challenging in
adult vertebrates. Owing to their transparency, zebrafish larvae have been used to
directly observe infection in vivo; however, such larvae ...
Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod.
(Drug Des Devel Ther, 2015)
Each year, despite optimal use of recommended acute and secondary prevention therapies,
4%-5% of patients with acute coronary syndrome (ACS) experience relapse of ACS or
other cardiovascular events including stroke, heart ...
A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data.
(Cereb Cortex, 2015-11)
Interest in structural brain connectivity has grown with the understanding that abnormal
neural connections may play a role in neurologic and psychiatric diseases. Small animal
connectivity mapping techniques are particularly ...
Angiotensin receptor neprilysin inhibition in heart failure: mechanistic action and clinical impact.
(J Card Fail, 2015-09)
Heart failure (HF) is an increasingly common syndrome associated with high mortality
and economic burden, and there has been a paucity over the past decade of new pharmacotherapies
that improve outcomes. However, recent ...
Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
(J Clin Invest, 2015-01)
Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine
kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling;
however, the functions of receptor PTPs in ...
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
(Clin Sci (Lond), 2015-11)
Schistosomiasis is a major cause of portal hypertension worldwide. It associates with
portal fibrosis that develops during chronic infection. The mechanisms by which the
pathogen evokes these host responses remain unclear. ...
Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.
(J Natl Cancer Inst, 2015-05)
Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated
whether these effects extend to solid tumors. Estrogen receptor-negative (ER-, 4T1)
and ER+ (E0771) tumor cells were implanted ...
In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.
(PLoS Genet, 2015-07)
African Americans have a disproportionate risk for developing nephropathy. This disparity
has been attributed to coding variants (G1 and G2) in apolipoprotein L1 (APOL1); however,
there is little functional evidence supporting ...