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Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer.
(Mol Carcinog, 2015-06)
CD133 is one of the most common stem cell markers, and functional single nucleotide
polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk
and patient survival. We hypothesized that potentially ...
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
(PloS one, 2013-01)
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs)
in its miRNA binding sites could modulate functions of the miRNA-target genes and
thus risk of cancers. In this study, we investigated ...
Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
(BMC cancer, 2011-06-20)
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase
family plays crucial roles in carcinogenesis and progression of several cancers, including
squamous cell carcinoma of the head and neck ...
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
(PLoS genetics, 2011-03-17)
Genome-wide association studies (GWAS) have been successful in identifying common
genetic variation involved in susceptibility to etiologically complex disease. We
conducted a GWAS to identify common genetic variation involved ...
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
(The Journal of investigative dermatology, 2013-07)
Melanoma is the most highly malignant skin cancer, and nucleotide excision repair
(NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients,
we evaluated whether genetic variants of NER genes ...
Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy.
(PloS one, 2011-01)
The repair of DNA double-strand breaks (DSBs) is the major mechanism to maintain genomic
stability in response to irradiation. We hypothesized that genetic polymorphisms in
DSB repair genes may affect clinical outcomes among ...
Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.
(BMC cancer, 2010-08-16)
Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving
in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms
may affect survival outcomes among locally advanced ...
Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.
(Journal of experimental & clinical cancer research : CR, 2011-01-07)
SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate,
changing the binding sites for extracellular growth factors. SULF1 expression has
been reported to be decreased in various cancers, including ...
Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.
(Journal of cellular and molecular medicine, 2013-07)
Recently, several studies have investigated the association between a newly reported
rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer
risk, but generated inconsistent findings. The present ...
ERCC1 and ERCC2 variants predict survival in gastric cancer patients.
(PloS one, 2013-01)
PURPOSE: ERCC1 and ERCC2 play critical roles in the nucleotide excision repair pathway
that effectively repairs DNA damage induced by chemotherapeutic agents. Therefore,
functional single nucleotide polymorphisms (SNPs) ...