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Photon-counting cine-cardiac CT in the mouse. 

Clark, Darin P; Holbrook, Matthew; Lee, Chang-Lung; Badea, Cristian T (PloS one, 2019-01)
The maturation of photon-counting detector (PCD) technology promises to enhance routine CT imaging applications with high-fidelity spectral information. In this paper, we demonstrate the power of this synergy and ...
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Spectral diffusion: an algorithm for robust material decomposition of spectral CT data. 

Clark, Darin P; Badea, Cristian T (Phys Med Biol, 2014-11-07)
Clinical successes with dual energy CT, aggressive development of energy discriminating x-ray detectors, and novel, target-specific, nanoparticle contrast agents promise to establish spectral CT as a powerful functional ...
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Spectrotemporal CT data acquisition and reconstruction at low dose. 

Clark, Darin P; Lee, Chang-Lung; Kirsch, David G; Badea, Cristian T (Med Phys, 2015-11)
PURPOSE: X-ray computed tomography (CT) is widely used, both clinically and preclinically, for fast, high-resolution anatomic imaging; however, compelling opportunities exist to expand its use in functional imaging applications. ...
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Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. 

Ashton, Jeffrey R; Clark, Darin P; Moding, Everett J; Ghaghada, Ketan; Kirsch, David G; West, Jennifer L; Badea, Cristian T (PLoS One, 2014)
PURPOSE: To provide additional functional information for tumor characterization, we investigated the use of dual-energy computed tomography for imaging murine lung tumors. Tumor blood volume and vascular permeability were ...
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A neural network-based method for spectral distortion correction in photon counting x-ray CT. 

Touch, Mengheng; Clark, Darin P; Barber, William; Badea, Cristian T (Physics in medicine and biology, 2016-08)
Spectral CT using a photon counting x-ray detector (PCXD) shows great potential for measuring material composition based on energy dependent x-ray attenuation. Spectral CT is especially suited for imaging with K-edge contrast ...
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Hybrid spectral CT reconstruction. 

Clark, Darin P; Badea, Cristian T (PLoS One, 2017)
Current photon counting x-ray detector (PCD) technology faces limitations associated with spectral fidelity and photon starvation. One strategy for addressing these limitations is to supplement PCD data with high-resolution, ...

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AuthorBadea, Cristian T (6)
Clark, Darin P (6)
Kirsch, David G (2)Lee, Chang-Lung (2)Ashton, Jeffrey R (1)Barber, William (1)Ghaghada, Ketan (1)Holbrook, Matthew (1)Moding, Everett J (1)Touch, Mengheng (1)... View MoreDate Issued2014 (2)2015 (1)2016 (1)2017 (1)2019 (1)TypeJournal article (6)Subject
Animals (6)
Mice (6)
Phantoms, Imaging (5)Tomography, X-Ray Computed (5)Algorithms (3)Contrast Media (3)Iodine (3)Photons (3)Radiographic Image Interpretation, Computer-Assisted (3)Gold (2)... View MoreAffiliation of Duke Author(s)
Clinical Science Departments (6)
Duke (6)Duke Cancer Institute (6)
Institutes and Centers (6)
Radiology (6)School of Medicine (6)Basic Science Departments (2)Biomedical Engineering (2)Pharmacology & Cancer Biology (2)Pratt School of Engineering (2)... View More
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