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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization.
(Cell Res, 2010-04)
BCL2 is best known as a multifunctional anti-apoptotic protein. However, little is
known about its role in cell-adhesive and motility events. Here, we show that BCL2
may play a role in the regulation of cell adhesion, spreading, ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
Interleukin-15 receptor blockade in non-human primate kidney transplantation.
(Transplantation, 2010-04-27)
BACKGROUND: Interleukin (IL)-15 is a chemotactic factor to T cells. It induces proliferation
and promotes survival of activated T cells. IL-15 receptor blockade in mouse cardiac
and islet allotransplant models has led to ...
Cryptococcal cell morphology affects host cell interactions and pathogenicity.
(PLoS Pathog, 2010-06-17)
Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size
of cryptococcal cells is typically 5 to 10 microm. Cell enlargement was observed in
vivo, producing cells up to 100 microm. These morphological ...
Evidence that SOX2 overexpression is oncogenic in the lung.
(PLoS One, 2010-06-10)
BACKGROUND: SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed
in some solid tumors, and is expressed in epithelial cells of the lung. METHODOLOGY/PRINCIPAL
FINDINGS: We show that SOX2 is ...
Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles.
(PLoS One, 2010-07-12)
In the event of a terrorist-mediated attack in the United States using radiological
or improvised nuclear weapons, it is expected that hundreds of thousands of people
could be exposed to life-threatening levels of ionizing ...
MicroRNA antagonism of the picornaviral life cycle: alternative mechanisms of interference.
(PLoS Pathog, 2010-03-19)
In addition to modulating the function and stability of cellular mRNAs, microRNAs
can profoundly affect the life cycles of viruses bearing sequence complementary targets,
a finding recently exploited to ameliorate toxicities ...
Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease.
(J Gene Med, 2010-11)
BACKGROUND: Lysosomal storage disorders such as Pompe disease can be more effectively
treated, if immune tolerance to enzyme or gene replacement therapy can be achieved.
Alternatively, immune responses against acid α-glucosidase ...
Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice.
(PLoS One, 2010-08-17)
BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation
of immune responses against resident intestinal bacteria within a genetically susceptible
host. Mast cells may play a critical role ...