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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 

Cao, L; Fermor, B; Griffin, TM; Guilak, Farshid; Huebner, JL; Kraus, Virginia Byers; Rodriguiz, Ramona M; ... (9 authors) (Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ...
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Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. 

Ahn, SH; Cowell, LG; Deshmukh, H; Fowler, Vance Garrison Jr; Johnson, N; Keum, S; Lamlertthon, S; ... (14 authors) (PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome ...
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MRP3: a molecular target for human glioblastoma multiforme immunotherapy. 

Bigner, DD; Herndon, James Emmett II; Kuan, Chien-Tsun; Lipp, Eric S; McLendon, Roger E; Pegram, CN; Rasheed, A; ... (11 authors) (BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and ...
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Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease. 

Sun, Baodong; Li, Songtao; Bird, Andrew; Yi, Haiqing; Kemper, Alex; Thurberg, Beth L; Koeberl, Dwight D (J Gene Med, 2010-11)
BACKGROUND: Lysosomal storage disorders such as Pompe disease can be more effectively treated, if immune tolerance to enzyme or gene replacement therapy can be achieved. Alternatively, immune responses against acid α-glucosidase ...
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Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. 

Chen, Benny J; Deoliveira, Divino; Spasojevic, Ivan; Sempowski, Gregory D; Jiang, Chen; Owzar, Kouros; Wang, Xiaojuan; ... (16 authors) (PLoS One, 2010-06-16)
Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to mitigate against radiation injury in mice and nonhuman primates. ...
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MRP3: a molecular target for human glioblastoma multiforme immunotherapy. 

Kuan, Chien-Tsun; Wakiya, Kenji; Herndon, James E; Lipp, Eric S; Pegram, Charles N; Riggins, Gregory J; Rasheed, Ahmed; ... (11 authors) (BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and ...
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Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. 

Kuan, Chien-Tsun; Chang, Jinli; Mansson, Jan-Eric; Li, Jianjun; Pegram, Charles; Fredman, Pam; McLendon, Roger E; ... (8 authors) (BMC Dev Biol, 2010-11-18)
BACKGROUND: Ganglioside biosynthesis occurs through a multi-enzymatic pathway which at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase utilizes a variety of galactose-terminated glycolipids ...

Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs. 

Neplioueva, Valentina; Dobrikova, Elena Y; Mukherjee, Neelanjan; Keene, Jack D; Gromeier, Matthias (PLoS One, 2010-07-23)
BACKGROUND: RNA-binding proteins accompany all steps in the life of mRNAs and provide dynamic gene regulatory functions for rapid adjustment to changing extra- or intracellular conditions. The association of RNA-binding ...
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Targeting A20 decreases glioma stem cell survival and tumor growth. 

Hjelmeland, Anita B; Wu, Qiulian; Wickman, Sarah; Eyler, Christine; Heddleston, John; Shi, Qing; Lathia, Justin D; ... (11 authors) (PLoS Biol, 2010-02-23)
Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be ...

Evidence that SOX2 overexpression is oncogenic in the lung. 

Lu, Yun; Futtner, Christopher; Rock, Jason R; Xu, Xia; Whitworth, Walter; Hogan, Brigid LM; Onaitis, Mark W (PLoS One, 2010-06-10)
BACKGROUND: SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung. METHODOLOGY/PRINCIPAL FINDINGS: We show that SOX2 is ...
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AuthorChao, Nelson J (3)Kuan, Chien-Tsun (3)McLendon, Roger E (3)Sempowski, Gregory D (3)Bigner, Darell D (2)Chen, Benny J (2)Chute, John P (2)Daher, Pamela (2)Deoliveira, Divino (2)Hogan, Brigid LM (2)... View MoreDate Issued
2010 (36)
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Humans (21)Mice, Inbred C57BL (14)Female (10)Blotting, Western (8)Male (8)Reverse Transcriptase Polymerase Chain Reaction (7)RNA, Messenger (7)Cells, Cultured (6)... View MoreAffiliation of Duke Author(s)
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School of Medicine (36)Duke Cancer Institute (29)Basic Science Departments (26)Medicine (20)Pathology (16)Molecular Genetics and Microbiology (11)Institutes and Provost's Academic Units (8)... View More
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