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An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
(Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate
cancer (CaP). We demonstrated that conditional ...
Preclinical and Coclinical Studies in Prostate Cancer.
(Cold Spring Harbor perspectives in medicine, 2018-04-02)
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably
succumb to their disease. Thus there remains a pressing need for preclinical testing
of new drugs and drug combinations for late-stage ...
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.
(Skeletal muscle, 2018-12-27)
BACKGROUND:β2-adrenergic receptors (β2ARs) are the target of catecholamines and play
fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An
important action of β2AR stimulation on skeletal muscle ...
Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes.
(PloS one, 2018-01)
Intact red blood cells (RBCs) are required for phenotypic analyses. In order to allow
separation (time and location) between subject encounter and sample analysis, we developed
a research-specific RBC cryopreservation protocol ...
Loss of LDAH associated with prostate cancer and hearing loss.
(Human molecular genetics, 2018-12)
Great strides in gene discovery have been made using a multitude of methods to associate
phenotypes with genetic variants, but there still remains a substantial gap between
observed symptoms and identified genetic defects. ...
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
(Nucleic acids research, 2018-09)
Genomic sequencing of hepatocellular carcinoma (HCC) uncovers a paucity of actionable
mutations, underscoring the necessity to exploit epigenetic vulnerabilities for therapeutics.
In HCC, EZH2-mediated H3K27me3 represents ...
Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.
(Immunity, 2018-01)
Despite recent advances, many cancers remain refractory to available immunotherapeutic
strategies. Emerging evidence indicates that the tolerization of local dendritic cells
(DCs) within the tumor microenvironment promotes ...