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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus
aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential
phenotype are unknown. Using chromosome ...
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
(Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate
cancer (CaP). We demonstrated that conditional ...
Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.
(Am J Transplant, 2012-10)
Even though the etiology of chronic rejection (CR) is multifactorial, donor specific
antibody (DSA) is considered to have a causal effect on CR development. Currently
the antibody-mediated mechanisms during CR are poorly ...
Snap-shot multispectral imaging of vascular dynamics in a mouse window-chamber model.
(Opt Lett, 2015-07-15)
Understanding tumor vascular dynamics through parameters such as blood flow and oxygenation
can yield insight into tumor biology and therapeutic response. Hyperspectral microscopy
enables optical detection of hemoglobin ...
Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate.
(PLoS One, 2014)
Subtle behavioral and cognitive deficits have been documented in patient cohorts with
orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated
with structural brain abnormalities but have ...
Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.
(PLoS One, 2010-06-16)
Medications that can mitigate against radiation injury are limited. In this study,
we investigated the ability of recombinant human growth hormone (rhGH) to mitigate
against radiation injury in mice and nonhuman primates. ...
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.
(Skeletal muscle, 2018-12-27)
BACKGROUND:β2-adrenergic receptors (β2ARs) are the target of catecholamines and play
fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An
important action of β2AR stimulation on skeletal muscle ...
Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
(BMC Dev Biol, 2010-11-18)
BACKGROUND: Ganglioside biosynthesis occurs through a multi-enzymatic pathway which
at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase
utilizes a variety of galactose-terminated glycolipids ...
CD20 deficiency in humans results in impaired T cell-independent antibody responses.
(J Clin Invest, 2010-01)
CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs
are commonly used for the treatment of B cell malignancies and autoantibody-mediated
autoimmune diseases. Despite this the role of CD20 ...