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Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study.

Kraus, Virginia; Reinke, Emily; Lattermann, Christian; Conley, Caitlin E-W; Johnson, Darren L; Huston, Laura J; Huebner, Janet L; ... (10 authors) (BioMed research international, 2018-01)

Background:The majority of patients develop posttraumatic osteoarthritis within 15 years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative biomarkers have been associated with both pain and ...

Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.

Chao, Nelson J; Chhabra, S; Corbet, K; Costa, L; Gasparetto, C; Green, MMB; Horwitz, A; ... (18 authors) (J Hematol Oncol, 2018-03-04)

BACKGROUND: The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized that blocking CXCR4/SDF-1 interaction after hematopoietic ...

Antibiotic overuse for acute respiratory tract infections in Sri Lanka: a qualitative study of outpatients and their physicians.

Arachchi, WK; Bodinayake, Champica K; Dabrera, T; Nagahawatte, A; Østbye, Truls; Sooriyaarachchi, A; Stewart, K; ... (10 authors) (BMC Fam Pract, 2018-03-01)

BACKGROUND: Acute respiratory tract infections (ARTIs) are a common reason for antibiotic overuse worldwide. We previously showed that over 80% of outpatients presenting to a tertiary care hospital in Sri Lanka ...

Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.

Troy, Jesse; Lee, Walter; Liu, Zhensheng; Wei, Qingyi; Han, Peng; Liu, Hongliang; Shi, Qiong; ... (10 authors) (Molecular carcinogenesis, 2018-06)

Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients ...

An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy.

Wei, Qingyi; Zhang, Ruoxin; Jia, Ming; Xu, Yuan; Qian, Danwen; Wang, Mengyun; Zhu, Meiling; ... (9 authors) (International journal of cancer, 2018-03)

Platinum-based chemotherapy (PBC) in combination with the 3rd generation drugs is the first-line treatment for patients with advanced non-small cell lung cancer (NSCLC); however, the efficacy is severely hampered by grade ...

Neural responses to emotional involuntary memories in posttraumatic stress disorder: Differences in timing and activity.

LaBar, Kevin; Rubin, David; Hall, Shana A; Brodar, Kaitlyn E; Berntsen, Dorthe (NeuroImage. Clinical, 2018-01)

Background:Involuntary memories are a hallmark symptom of posttraumatic stress disorder (PTSD), but studies of the neural basis of involuntary memory retrieval in posttraumatic stress disorder (PTSD) are sparse. The study ...

Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival.

Wei, Qingyi; Li, Bo; Wang, Yanru; Xu, Yinghui; Liu, Hongliang; Bloomer, Wendy; Zhu, Dakai; ... (12 authors) (International journal of cancer, 2018-06)

Cutaneous melanoma (CM) is considered as a steroid hormone-related malignancy. However, few studies have evaluated the roles of genetic variants encoding steroid hormone receptor genes and their related regulators (SHR-related ...

Survival Benefit of Germline BRCA Mutation is Associated with Residual Disease in Ovarian Cancer.

Wei, Qingyi; Shi, Tingyan; Wang, Pan; Tang, Wenbin; Jiang, Rong; Yin, Sheng; Shi, Di; ... (9 authors) (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018-01)

BACKGROUND/AIMS:Prognostic value of germline BRCA1 or BRCA2 (gBRCA1/2) mutations in epithelial ovarian cancer (EOC) remains controversial, especially in the estimation of long-term survival. We previously reported the largest ...

Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy.

Liu, Zhensheng; Wei, Qingyi; Wen, Juyi; Liu, Hongliang; Wang, Lili; Wang, Xiaomeng; Gu, Ning; ... (11 authors) (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018-05)

INTRODUCTION:Autophagy not only plays an important role in the progression of cancer but is also involved in tissue inflammatory response. However, few published studies have investigated associations between functional ...

The Improvement Readiness scale of the SCORE survey: a metric to assess capacity for quality improvement in healthcare.

Boulus, Kathryn; Mosca, Paul; Sexton, John; Quow, Krystina; Frankel, Allan; Profit, Jochen; Hadley, Allison; ... (9 authors) (BMC health services research, 2018-12-17)

BACKGROUND:Quality improvement efforts are inextricably linked to the readiness of healthcare workers to take them on. The current study aims to clarify the nature and measurement of Improvement Readiness (IR) by 1) examining ...