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Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.
(PloS one, 2012-01)
Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important
role in nucleotide excision repair and participates in removal of DNA interstrand
cross-links and DNA double-strand breaks. Single nucleotide ...
Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.
(The Journal of investigative dermatology, 2015-02)
Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway
involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using
data derived from published genome-wide association ...
Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study.
(BioMed research international, 2018-01)
Background:The majority of patients develop posttraumatic osteoarthritis within 15
years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative
biomarkers have been associated with both pain and ...
The dynamics of proactive and reactive cognitive control processes in the human brain.
(J Cogn Neurosci, 2014-05)
In this study, we leveraged the high temporal resolution of EEG to examine the neural
mechanisms underlying the flexible regulation of cognitive control that unfolds over
different timescales. We measured behavioral and ...
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans.
(Diabetes, 2010-09)
OBJECTIVE: The orexigenic gut hormone ghrelin and its receptor are present in pancreatic
islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin
secretion in humans has not been established. ...
Exercise-induced pain intensity predicted by pre-exercise fear of pain and pain sensitivity.
(Clin J Pain, 2011-06)
OBJECTIVES: Our primary goals were to determine whether preexisting fear of pain and
pain sensitivity contributed to post-exercise pain intensity. METHODS: Delayed-onset
muscle pain was induced in the trunk extensors of ...
Hypertension and obesity as cardiovascular risk factors among HIV seropositive patients in Western Kenya.
(PLoS One, 2011)
BACKGROUND: There is increased risk of cardiovascular disease among HIV seropositive
individuals. The prevalence of HIV is highest in sub-Saharan Africa; however, HIV-related
cardiovascular risk research is largely derived ...
Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records.
(BMC Infect Dis, 2014-05-22)
BACKGROUND: Mortality among people with human immunodeficiency virus (HIV) infection
is increasingly due to non-communicable causes. This has been observed mostly in developed
countries and the routine care of HIV infected ...
Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.
(Kidney Int, 2014-12)
Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes,
including inherited genetic defects, with significant proteinuria being the predominant
clinical finding at presentation. Mutations in ...
Adaptive intervention design in mobile health: Intervention design and development in the Cell Phone Intervention for You trial.
(Clin Trials, 2015-12)
BACKGROUND/AIMS: The obesity epidemic has spread to young adults, and obesity is a
significant risk factor for cardiovascular disease. The prominence and increasing
functionality of mobile phones may provide an opportunity ...