Now showing items 1-10 of 13
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.
(The journals of gerontology. Series A, Biological sciences and medical sciences, 2018-05-22)
Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first ...
PHYSIOLOGICAL DYSREGULATION AS PROMISING MEASURE OF ROBUSTNESS AND RESILIENCE IN AGING STUDIES
The Wnt5a-β-catenin Pathway Triggers a Metabolic Switch That Drives Indoleamine 2,3-dioxygenase Activity and Dendritic Cell Tolerization in the Melanoma Microenvironment.
(Journal for ImmunoTherapy of Cancer, 2017-04-13)
Partition functions from rao-blackwellized tempered sampling
(33rd International Conference on Machine Learning, ICML 2016, 2016-01-01)
© 2016 by the author(s). Partition functions of probability distributions are important quantities for model evaluation and comparisons. We present a new method to compute partition functions of complex and multi-modal ...
Myeloablative conditioning with total body irradiation for AML: Balancing survival and pulmonary toxicity.
(Adv Radiat Oncol, 2016-10)
PURPOSE: The purpose of this study was to compare leukemia-free survival (LFS) and other clinical outcomes in patients with acute myelogenous leukemia who underwent a myeloablative allogeneic stem cell transplant with and ...
A Spatio-temporal Coupling Method to Reduce the Time-to-Solution of Cardiovascular Simulations
We present a new parallel-in-time method designed to reduce the overall time-to-solution of a patient-specific cardiovascular flow simulation. Using a modified Para real algorithm, our approach extends strong scalability ...
TRENDS IN DIABETES MELLITUS AND RELATED HEALTH OUTCOMES 1991-2013: ACHIEVEMENTS AND CHALLENGES
Resistance to stresses and reliability of biological systems: Insights for genetic studies of human aging, health, and longevity
(Proceedings - 2nd International Symposium on Stochastic Models in Reliability Engineering, Life Science, and Operations Management, SMRLO 2016, 2016-03-11)
© 2016 IEEE.Connection between stress resistance and longevity in biological organisms is widely discussed and confirmed experimentally. Much less is known about the roles of genetic and non-genetic factors in regulation ...
T CELL REACTIVITY IN INCLUSION BODY MYOSITIS (IBM)
(MUSCLE & NERVE, 2015-09)
RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin.
Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. ...