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Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
(Scientific reports, 2015-01)
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway
may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1
and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...
Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2015-12)
Published data on the association between PRKAA1 rs13361707 T > C polymorphism and
gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation
of the association, we conducted a large-scale ...
TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy.
(Medicine, 2015-11)
Acute toxicity is the main dose-limiting factor in the chemoradiotherapy of rectal
cancer patients and depends on several pro-inflammatory factors, including interleukin-1
(IL-1), IL-6, and tumor necrosis factor-alpha (TNF-α). ...
Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
(PloS one, 2012-01)
BACKGROUND: Recent genome-wide association studies (GWAS) have found a single nucleotide
polymorphism (SNP, rs2274223 A>G) in PLCE1 to be associated with risk of gastric adenocarcinoma.
In the present study, we validated ...
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
(BMC cancer, 2011-01)
BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1
(APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1
promoter -141T/G variant (rs1760944) has been reported ...
Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.
(PloS one, 2012-01)
BACKGROUND: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune
and pro-inflammatory response, and genetic polymorphisms of candidate genes involved
in autoimmune and pro-inflammatory response ...
On the interplay of telomeres, nevi and the risk of melanoma.
(PloS one, 2012-01)
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres
have been found to be associated with many cancers and with number of nevi, a known
risk factor for melanoma. However, shorter telomeres ...
RAD52 variants predict platinum resistance and prognosis of cervical cancer.
(PloS one, 2012-01)
RAD52 is an important but not well characterized homologous recombination repair gene
that can bind to single-stranded DNA ends and mediate the DNA-DNA interaction necessary
for the annealing of complementary DNA strands. ...
Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial.
(World journal of surgical oncology, 2012-01)
BACKGROUND: HER-2/neu-targeted therapy has been successfully used in advanced gastric
cancer, but the role of HER-2/neu in the prognosis of gastric cancer is not yet clear.
In this study, we investigated the correlation ...
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
(PLoS genetics, 2011-03-17)
Genome-wide association studies (GWAS) have been successful in identifying common
genetic variation involved in susceptibility to etiologically complex disease. We
conducted a GWAS to identify common genetic variation involved ...