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Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.

Allgood, S; Amos, JD; Cohen, MS; Eron, JJ; Goepfert, Paul A; Gurley, TC; Haynes, Barton Ford; ... (25 authors) (PLoS Med, 2009-07-07)

BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ...

Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.

Bigner, DD; Desjardins, A; Friedman, AH; Friedman, HS; Gururangan, Sridharan; Herndon, James Emmett II; Marcello, JE; ... (13 authors) (Br J Cancer, 2009-12-15)

BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including 27 with glioblastoma (GBM) and 32 with grade ...

Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance.

Becher, H; Chierakul, W; Day, NP; Fowler, Vance Garrison Jr; Hongsuwan, M; Limmathurotsakul, D; Mahavanakul, W; ... (16 authors) (PLoS One, 2009)

BACKGROUND: Most information on invasive Staphylococcus aureus infections comes from temperate countries. There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus ...

Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.

Wei, Qingyi; Zhai, Xiangjun; Gao, Jun; Hu, Zhibin; Tang, Jinhai; Qin, Jianwei; Wang, Shui; ... (14 authors) (BMC cancer, 2006-01)

BACKGROUND: Accumulative evidence suggests that low folate intake is associated with increased risk of breast cancer. Polymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, ...

Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.

Wei, Qingyi; Yang, Miao; Wu, Tangchun; Cheng, Longxian; Wang, Feng; Tanguay, Robert M (Respiratory research, 2005-01)

BACKGROUND: The heat shock proteins (Hsps) are induced by stresses such as allergic factors and inflammatory responses in bronchi epithelial cells and therefore may be detectable in patients with asthma. However, the etiologic ...

The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

Wei, Qingyi; Guan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tang, Dongfeng; Ajani, Jaffer A (BMC gastroenterology, 2009-10-16)

Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression ...