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HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.
(Journal of virology, 2018-04)
Induction of broadly cross-reactive antiviral humoral responses with the capacity
to target globally diverse circulating strains is a key goal for HIV-1 immunogen design.
A major gap in the field is the identification of ...
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.
(Nature immunology, 2017-09)
The balance of myeloid populations and lymphoid populations must be well controlled.
Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions
such as infection and autoimmunity. Notably, two ...
Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
(Nat Med, 2013-03)
The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive
injury are not well understood. We identified epidermal growth factor (EGF) to be
highly enriched in the bone marrow serum of ...
Leptin metabolically licenses T cells for activation to link nutrition and immunity.
(J Immunol, 2014-01-01)
Immune responses are highly energy-dependent processes. Activated T cells increase
glucose uptake and aerobic glycolysis to survive and function. Malnutrition and starvation
limit nutrients and are associated with immune ...
Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.
(J Virol, 2013-10)
Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs),
rarely transmit SIV via breast-feeding. In order to examine the genetic diversity
of breast milk SIV variants in this limited-transmission ...
Metabolic regulation of T lymphocytes.
(Annu Rev Immunol, 2013)
T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens
and to orchestrate the action of other immune cells. Quiescent T cells require predominantly
ATP-generating processes, whereas ...
CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections.
(Dis Model Mech, 2015-12)
Visualization of infection and the associated host response has been challenging in
adult vertebrates. Owing to their transparency, zebrafish larvae have been used to
directly observe infection in vivo; however, such larvae ...
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
(J Immunol, 2011-03-15)
Stimulated CD4(+) T lymphocytes can differentiate into effector T cell (Teff) or inducible
regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff
and Treg require distinct metabolic programs ...
Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
(PLoS One, 2013)
Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with
high grade glioma and is routinely used to treat melanoma brain metastases. A prominent
side effect of TMZ is induction of profound lymphopenia, ...
MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
(Cancer Cell, 2016-01-11)
The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating
cells (GICs) that are critical for glioblastoma (GBM) occurrence and recurrence. Here,
we report that hypoxia-induced miR-215 is ...