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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus
aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential
phenotype are unknown. Using chromosome ...
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells.
(J Clin Invest, 2015-02)
Satiety and other core physiological functions are modulated by sensory signals arising
from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors
called enteroendocrine cells. Despite being ...
Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
(J Clin Invest, 2015-01)
Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine
kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling;
however, the functions of receptor PTPs in ...
Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.
(MBio, 2015-04-21)
UNLABELLED: Broadly cross-reactive neutralizing antibodies (bNabs) represent powerful
tools to combat human immunodeficiency virus type 1 (HIV-1) infection. Here, we examined
whether HIV-1-specific bNabs are capable ...
CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation.
(Genome Biol, 2015-09-15)
Meta-analyses of genome-wide association studies (GWAS) have demonstrated that the
same genetic variants can be associated with multiple diseases and other complex traits.
We present software called CPAG (Cross-Phenotype ...
Angiotensin receptor neprilysin inhibition in heart failure: mechanistic action and clinical impact.
(J Card Fail, 2015-09)
Heart failure (HF) is an increasingly common syndrome associated with high mortality
and economic burden, and there has been a paucity over the past decade of new pharmacotherapies
that improve outcomes. However, recent ...
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
(PLoS Pathog, 2015-08)
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through
mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing
antibodies (bnAbs) are the type of HIV-1 antibodies ...
Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod.
(Drug Des Devel Ther, 2015)
Each year, despite optimal use of recommended acute and secondary prevention therapies,
4%-5% of patients with acute coronary syndrome (ACS) experience relapse of ACS or
other cardiovascular events including stroke, heart ...
Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.
(PLoS Pathog, 2014-08)
Ongoing Cryptococcus gattii outbreaks in the Western United States and Canada illustrate
the impact of environmental reservoirs and both clonal and recombining propagation
in driving emergence and expansion of microbial ...