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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 

Cao, L; Fermor, B; Griffin, TM; Guilak, Farshid; Huebner, JL; Kraus, Virginia Byers; Rodriguiz, Ramona M; ... (9 authors) (Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ...
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Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia. 

Arumugam, Ramamani; Brooks, ED; Curtis, S; Demaster, A; Freemark, Michael Scott; Jackson, MW; Kishnani, Priya Sunil; ... (11 authors) (Mol Genet Metab, 2013-06)
Glycogen Storage Disease type Ia (GSD-Ia) in humans frequently causes delayed bone maturation, decrease in final adult height, and decreased growth velocity. This study evaluates the pathogenesis of growth failure and the ...
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Interstitial engraftment of adipose-derived stem cells into an acellular dermal matrix results in improved inward angiogenesis and tissue incorporation. 

Erdmann, D; Hollenbeck, ST; Klitzman, Bruce; Komatsu, I; Levin, LS; Yang, J; Zhang, Y (J Biomed Mater Res A, 2013-10)
Acellular dermal matrices (ADM) are commonly used in reconstructive procedures and rely on host cell invasion to become incorporated into host tissues. We investigated different approaches to adipose-derived stem cells (ASCs) ...
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Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. 

Ahn, SH; Cowell, LG; Deshmukh, H; Fowler, Vance Garrison Jr; Johnson, N; Keum, S; Lamlertthon, S; ... (14 authors) (PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome ...
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MRP3: a molecular target for human glioblastoma multiforme immunotherapy. 

Bigner, DD; Herndon, James Emmett II; Kuan, Chien-Tsun; Lipp, Eric S; McLendon, Roger E; Pegram, CN; Rasheed, A; ... (11 authors) (BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and ...
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An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. 

Chen, Ming; Zhang, Jiangwen; Sampieri, Katia; Clohessy, John G; Mendez, Lourdes; Gonzalez-Billalabeitia, Enrique; Liu, Xue-Song; ... (23 authors) (Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). We demonstrated that conditional ...
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Preclinical and Coclinical Studies in Prostate Cancer. 

Chen, Ming; Pandolfi, Pier Paolo (Cold Spring Harbor perspectives in medicine, 2018-04-02)
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage ...
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Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models. 

Chen, Ming; Yeh, Chiuan-Ren; Chang, Hong-Chiang; Vitkus, Spencer; Wen, Xing-Qiao; Bhowmick, Neil A; Wolfe, Andrew; ... (8 authors) (The Journal of pathology, 2012-01)
Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the prostate and oestrogen receptor (ER) α is required to mediate this response. Previous studies utilizing tissue recombination with seminal ...
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Photon-counting cine-cardiac CT in the mouse. 

Clark, Darin P; Holbrook, Matthew; Lee, Chang-Lung; Badea, Cristian T (PloS one, 2019-01)
The maturation of photon-counting detector (PCD) technology promises to enhance routine CT imaging applications with high-fidelity spectral information. In this paper, we demonstrate the power of this synergy and ...
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Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing. 

Chinnadurai, Raghavan; Copland, Ian B; Garcia, Marco A; Petersen, Christopher T; Lewis, Christopher N; Waller, Edmund K; Kirk, Allan D; ... (8 authors) (Stem cells (Dayton, Ohio), 2016-09)
We have previously demonstrated that cryopreservation and thawing lead to altered Mesenchymal stromal cells (MSC) functionalities. Here, we further analyzed MSC's fitness post freeze-thaw. We have observed that thawed MSC ...
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AuthorChen, Ming (12)Badea, Cristian T (9)Pandolfi, Pier Paolo (9)Bursac, Nenad (8)Kirsch, David G (8)Chute, John P (7)Johnson, G Allan (7)Montefiori, David C (7)Bigner, Darell D (6)Chao, Nelson J (6)... View MoreDate Issued2010 (49)2014 (32)2015 (32)2013 (27)2012 (19)2016 (19)2011 (11)2018 (9)2017 (6)2019 (1)Type
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