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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia.
(Mol Genet Metab, 2013-06)
Glycogen Storage Disease type Ia (GSD-Ia) in humans frequently causes delayed bone
maturation, decrease in final adult height, and decreased growth velocity. This study
evaluates the pathogenesis of growth failure and the ...
Interstitial engraftment of adipose-derived stem cells into an acellular dermal matrix results in improved inward angiogenesis and tissue incorporation.
(J Biomed Mater Res A, 2013-10)
Acellular dermal matrices (ADM) are commonly used in reconstructive procedures and
rely on host cell invasion to become incorporated into host tissues. We investigated
different approaches to adipose-derived stem cells (ASCs) ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus
aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential
phenotype are unknown. Using chromosome ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
(Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate
cancer (CaP). We demonstrated that conditional ...
Preclinical and Coclinical Studies in Prostate Cancer.
(Cold Spring Harbor perspectives in medicine, 2018-04-02)
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably
succumb to their disease. Thus there remains a pressing need for preclinical testing
of new drugs and drug combinations for late-stage ...
Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
(The Journal of pathology, 2012-01)
Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the
prostate and oestrogen receptor (ER) α is required to mediate this response. Previous
studies utilizing tissue recombination with seminal ...
Photon-counting cine-cardiac CT in the mouse.
(PloS one, 2019-01)
The maturation of photon-counting detector (PCD) technology promises to enhance routine
CT imaging applications with high-fidelity spectral information. In this paper, we
demonstrate the power of this synergy and ...
Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing.
(Stem cells (Dayton, Ohio), 2016-09)
We have previously demonstrated that cryopreservation and thawing lead to altered
Mesenchymal stromal cells (MSC) functionalities. Here, we further analyzed MSC's fitness
post freeze-thaw. We have observed that thawed MSC ...