Search
Now showing items 1-10 of 45
Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee.
(Retrovirology, 2017-06-02)
Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of human immunodeficiency
virus type 1 (HIV-1), is associated with increased mortality and AIDS-like immunopathology
in wild-living chimpanzees ...
Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.
(Immunity, 2018-01)
Despite recent advances, many cancers remain refractory to available immunotherapeutic
strategies. Emerging evidence indicates that the tolerization of local dendritic cells
(DCs) within the tumor microenvironment promotes ...
DOK2 inhibits EGFR-mutated lung adenocarcinoma.
(PloS one, 2013-01)
Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas
and the importance of EGFR mutations for the initiation and maintenance of lung cancer
is well established from mouse models and cancer ...
Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.
(Transplantation, 2015-12)
BACKGROUND: Blocking leukocyte function-associated antigen (LFA)-1 in organ transplant
recipients prolongs allograft survival. However, the precise mechanisms underlying
the therapeutic potential of LFA-1 blockade in preventing ...
A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data.
(Cereb Cortex, 2015-11)
Interest in structural brain connectivity has grown with the understanding that abnormal
neural connections may play a role in neurologic and psychiatric diseases. Small animal
connectivity mapping techniques are particularly ...
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.
(Arthritis Res Ther, 2012-04-17)
INTRODUCTION: Osteoarthritis (OA) results in pain and disability; however, preclinical
OA models often focus on joint-level changes. Gait analysis is one method used to
evaluate both preclinical OA models and OA patients. ...
Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia.
(Mol Genet Metab, 2013-06)
Glycogen Storage Disease type Ia (GSD-Ia) in humans frequently causes delayed bone
maturation, decrease in final adult height, and decreased growth velocity. This study
evaluates the pathogenesis of growth failure and the ...
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
(Clin Sci (Lond), 2015-11)
Schistosomiasis is a major cause of portal hypertension worldwide. It associates with
portal fibrosis that develops during chronic infection. The mechanisms by which the
pathogen evokes these host responses remain unclear. ...
Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.
(Am J Transplant, 2012-09)
Chronic allograft rejection is a major impediment to long-term transplant success.
Humoral immune responses to alloantigens are a growing clinical problem in transplantation,
with mounting evidence associating alloantibodies ...
A model of sequential heart and composite tissue allotransplant in rats.
(Plast Reconstr Surg, 2010-07)
BACKGROUND: Some of the 600,000 patients with solid organ allotransplants need reconstruction
with a composite tissue allotransplant, such as the hand, abdominal wall, or face.
The aim of this study was to develop a rat ...