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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 

Cao, L; Fermor, B; Griffin, TM; Guilak, Farshid; Huebner, JL; Kraus, Virginia Byers; Rodriguiz, Ramona M; ... (9 authors) (Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ...
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Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. 

Ahn, SH; Cowell, LG; Deshmukh, H; Fowler, Vance Garrison Jr; Johnson, N; Keum, S; Lamlertthon, S; ... (14 authors) (PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome ...
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An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. 

Chen, Ming; Zhang, Jiangwen; Sampieri, Katia; Clohessy, John G; Mendez, Lourdes; Gonzalez-Billalabeitia, Enrique; Liu, Xue-Song; ... (23 authors) (Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). We demonstrated that conditional ...
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Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing. 

Chinnadurai, Raghavan; Copland, Ian B; Garcia, Marco A; Petersen, Christopher T; Lewis, Christopher N; Waller, Edmund K; Kirk, Allan D; ... (8 authors) (Stem cells (Dayton, Ohio), 2016-09)
We have previously demonstrated that cryopreservation and thawing lead to altered Mesenchymal stromal cells (MSC) functionalities. Here, we further analyzed MSC's fitness post freeze-thaw. We have observed that thawed MSC ...
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Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment. 

Kwun, J; Oh, BC; Gibby, AC; Ruhil, R; Lu, VT; Kim, DW; Page, EK; ... (13 authors) (Am J Transplant, 2012-10)
Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody-mediated mechanisms during CR are poorly ...
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Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. 

Quarmyne, Mamle; Doan, Phuong L; Himburg, Heather A; Yan, Xiao; Nakamura, Mai; Zhao, Liman; Chao, Nelson J; ... (8 authors) (J Clin Invest, 2015-01)
Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling; however, the functions of receptor PTPs in ...
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Snap-shot multispectral imaging of vascular dynamics in a mouse window-chamber model. 

Hendargo, Hansford C; Zhao, Yulin; Allenby, Taylor; Palmer, Gregory M (Opt Lett, 2015-07-15)
Understanding tumor vascular dynamics through parameters such as blood flow and oxygenation can yield insight into tumor biology and therapeutic response. Hyperspectral microscopy enables optical detection of hemoglobin ...
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Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis. 

Furman, Bridgette D; Mangiapani, Daniel S; Zeitler, Evan; Bailey, Karsyn N; Horne, Phillip H; Huebner, Janet L; Kraus, Virginia B; ... (9 authors) (Arthritis Res Ther, 2014-06-25)
INTRODUCTION: Post-traumatic arthritis (PTA) is a progressive, degenerative response to joint injury, such as articular fracture. The pro-inflammatory cytokines, interleukin 1(IL-1) and tumor necrosis factor alpha (TNF-α), ...
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Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate. 

Lipinski, Robert J; Holloway, Hunter T; O'Leary-Moore, Shonagh K; Ament, Jacob J; Pecevich, Stephen J; Cofer, Gary P; Budin, Francois; ... (10 authors) (PLoS One, 2014)
Subtle behavioral and cognitive deficits have been documented in patient cohorts with orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated with structural brain abnormalities but have ...
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CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections. 

Cronan, Mark R; Rosenberg, Allison F; Oehlers, Stefan H; Saelens, Joseph W; Sisk, Dana M; Jurcic Smith, Kristen L; Lee, Sunhee; ... (8 authors) (Dis Model Mech, 2015-12)
Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been used to directly observe infection in vivo; however, such larvae ...
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AuthorChao, Nelson J (4)Chute, John P (4)Sempowski, Gregory D (4)Badea, Cristian T (2)Bigner, Darell D (2)Burlingham, William J (2)Caron, Marc G (2)Clark, Darin P (2)Daher, Pamela (2)Doan, Phuong L (2)... View MoreDate Issued2010 (14)2015 (8)2013 (5)2012 (4)2014 (4)2016 (4)2011 (3)2018 (3)Type
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