Search
Now showing items 1-10 of 45
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus
aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential
phenotype are unknown. Using chromosome ...
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
(Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate
cancer (CaP). We demonstrated that conditional ...
Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing.
(Stem cells (Dayton, Ohio), 2016-09)
We have previously demonstrated that cryopreservation and thawing lead to altered
Mesenchymal stromal cells (MSC) functionalities. Here, we further analyzed MSC's fitness
post freeze-thaw. We have observed that thawed MSC ...
Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.
(Am J Transplant, 2012-10)
Even though the etiology of chronic rejection (CR) is multifactorial, donor specific
antibody (DSA) is considered to have a causal effect on CR development. Currently
the antibody-mediated mechanisms during CR are poorly ...
Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
(J Clin Invest, 2015-01)
Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine
kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling;
however, the functions of receptor PTPs in ...
Snap-shot multispectral imaging of vascular dynamics in a mouse window-chamber model.
(Opt Lett, 2015-07-15)
Understanding tumor vascular dynamics through parameters such as blood flow and oxygenation
can yield insight into tumor biology and therapeutic response. Hyperspectral microscopy
enables optical detection of hemoglobin ...
Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis.
(Arthritis Res Ther, 2014-06-25)
INTRODUCTION: Post-traumatic arthritis (PTA) is a progressive, degenerative response
to joint injury, such as articular fracture. The pro-inflammatory cytokines, interleukin
1(IL-1) and tumor necrosis factor alpha (TNF-α), ...
Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate.
(PLoS One, 2014)
Subtle behavioral and cognitive deficits have been documented in patient cohorts with
orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated
with structural brain abnormalities but have ...
CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections.
(Dis Model Mech, 2015-12)
Visualization of infection and the associated host response has been challenging in
adult vertebrates. Owing to their transparency, zebrafish larvae have been used to
directly observe infection in vivo; however, such larvae ...