Now showing items 1-2 of 2

    • A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. 

      Dewhirst, Mark Wesley; Geradts, J; Henao, R; Kim, J; Kim, WJ; Kornbluth, S; Kurokawa, M; ... (15 authors) (Sci Signal, 2013-05-07)
      In the intrinsic pathway of apoptosis, cell-damaging signals promote the release of cytochrome c from mitochondria, triggering activation of the Apaf-1 and caspase-9 apoptosome. The ubiquitin E3 ligase MDM2 decreases the ...
    • X-Ray Psoralen Activated Cancer Therapy (X-PACT). 

      Adamson, Justus D; Alcorta, DA; Beyer, WF; Dewhirst, Mark Wesley; Dodd, RD; Fathi, Z; Fecci, Peter Edward; ... (20 authors) (PLoS One, 2016)
      This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with current application to proliferative ...