Now showing items 1-7 of 7

    • Development of a Novel c-MET-Based CTC Detection Platform. 

      Abbruzzese, J; Armstrong, AJ; Boominathan, R; Connelly, MA; Foulk, B; Garcia-Blanco, Mariano Agustin; Gemberling, S; ... (20 authors) (Mol Cancer Res, 2016-06)
      UNLABELLED: Amplification of the MET oncogene is associated with poor prognosis, metastatic dissemination, and drug resistance in many malignancies. We developed a method to capture and characterize circulating tumor cells ...
    • Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. 

      Armstrong, AJ; Bepler, T; Buckley, Anne Frances; Epstein, JI; Garcia-Blanco, Mariano Agustin; Hish, AJ; Marengo, MS; ... (13 authors) (Oncogene, 2016-08-18)
      The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT and MET). Although there is substantial support ...
    • Docetaxel Resistance in Prostate Cancer: Taking It Up a Notch. 

      Zhang, T; Armstrong, AJ (Clin Cancer Res, 2015-10-15)
      Notch signaling is implicated in prostate cancer progression and docetaxel resistance. Cui and colleagues describe the additive efficacy and mechanisms of a γ-secretase inhibitor, PF-03084014, and docetaxel in preclinical ...
    • Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer. 

      Armstrong, AJ; Freedland, SJ; Halabi, Susan; Healy, Patrick; Kemeny, G; Lark, A; Vollmer, Robin T; ... (8 authors) (Prostate Cancer Prostatic Dis, 2016-03)
      BACKGROUND: Given the potential importance of epithelial plasticity (EP) to cancer metastasis, we sought to investigate biomarkers related to EP in men with localized prostate cancer (PC) for the association with time to ...
    • Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells. 

      Brian, Leigh; Freedman, NJ; Gurley, SB; Hauser, Elizabeth Rebecca; Lawson, JH; Mattocks, N; Nagi, K; ... (12 authors) (Cardiovasc Res, 2017-11-01)
      Aims: Chronic kidney disease (CKD) is a powerful independent risk factor for cardiovascular events, including vein graft failure. Because CKD impairs the clearance of small proteins, we tested the hypothesis that CKD exacerbates ...
    • Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2. 

      Armstrong, Andrew John; Bartholf DeWitt, Suzanne; Eward, William Curtis; Garcia-Blanco, Mariano Agustin; Gilja, Shivee; Hish, A; Jolly, MK; ... (12 authors) (Mol Cell Biol, 2016-10-01)
      Phenotypic plasticity involves a process in which cells transiently acquire phenotypic traits of another lineage. Two commonly studied types of phenotypic plasticity are epithelial-mesenchymal transition (EMT) and ...
    • Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer. 

      Armstrong, Andrew John; Foo, W-C; Freedman, J; Garcia-Blanco, Mariano Agustin; Li, J; Park, S; Patierno, SR; ... (11 authors) (Oncotarget, 2016-08-02)
      Treatment with androgen-targeted therapies can induce upregulation of epithelial plasticity pathways. Epithelial plasticity is known to be important for metastatic dissemination and therapeutic resistance. The goal of this ...