Now showing items 1-1 of 1

    • Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. 

      Souma, Tomokazu; Thomson, Benjamin R; Heinen, Stefan; Anna Carota, Isabel; Yamaguchi, Shinji; Onay, Tuncer; Liu, Pan; ... (16 authors) (Proceedings of the National Academy of Sciences of the United States of America, 2018-02)
      The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ...