Now showing items 1-5 of 5

    • Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals. 

      Center for HIV/AIDS Vaccine Immunology; Dang, KK; Descombes, P; Fellay, J; Feng, S; Ge, Dongliang; Goldstein, David Benjamin; ... (13 authors) (PLoS Pathog, 2010-02-26)
      There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, ...
    • Genome-wide scan of copy number variation in late-onset Alzheimer's disease. 

      Burke, JR; Chiba-Falek, O; Goldstein, David Benjamin; Hayden, Kathleen M; Heinzen, EL; Hulette, Christine Marie; Need, AC; ... (10 authors) (J Alzheimers Dis, 2010)
      Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted ...
    • Screening the human exome: a comparison of whole genome and whole transcriptome sequencing. 

      Center for HIV/AIDS Vaccine Immunology (CHAVI); Cirulli Rogers, Elizabeth T; Ge, Dongliang; Goedert, JJ; Goldstein, David Benjamin; Heinzen, EL; Maia, JM; ... (10 authors) (Genome Biol, 2010)
      BACKGROUND: There is considerable interest in the development of methods to efficiently identify all coding variants present in large sample sets of humans. There are three approaches possible: whole-genome sequencing, ...
    • The characterization of twenty sequenced human genomes. 

      Campbell, CR; Cirulli Rogers, Elizabeth T; Dickson, SP; Fellay, J; Ge, Dongliang; Goedert, JJ; Goldstein, David Benjamin; ... (25 authors) (PLoS Genet, 2010-09-09)
      We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals ...
    • Tissue-specific genetic control of splicing: implications for the study of complex traits. 

      Cronin, KD; Denny, Thomas Norton; Gabriel, WN; Ge, Dongliang; Goldstein, David Benjamin; Heinzen, EL; Hulette, Christine Marie; ... (10 authors) (PLoS Biol, 2008-12-23)
      Numerous genome-wide screens for polymorphisms that influence gene expression have provided key insights into the genetic control of transcription. Despite this work, the relevance of specific polymorphisms to in vivo expression ...