Browsing Scholarly Articles by Author "Muoio, DM"

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.

Chi, JT; Cyr, Derek; Huang, Z; Ilkayeva, Olga; Keenan, MM; Kim, So Young; Liu, B; ... (14 authors) (PLoS Genet, 2015-10)

In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell ...

Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.

Ayer, DE; Chen, JL; Chi, JT; Liu, PY; Merl, D; Muoio, DM; Peterson, CW; ... (10 authors) (PLoS Genet, 2010-09-02)

Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional ...

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.

Bain, James R; Craig, Damian; Grass, E; Gregory, Simon Gray; Hauser, Elizabeth Rebecca; Haynes, Carol; Kraus, William Erle; ... (16 authors) (PLoS Genet, 2015-11)

Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) ...

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.

Andonian, Brian; Campbell, M; Davis, BN; Gilmore, BF; Hubal, MJ; Huebner, JL; Huffman, Kim Marie; ... (15 authors) (Arthritis Res Ther, 2017-01-23)

BACKGROUND: To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA. METHODS: Persons with seropositive or erosive RA (n = 51) and control subjects ...