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    • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 

      Blake, EJ; Bradner, JE; Bryson, BD; Cannell, IG; Carpenter, AE; Chen, CC; Chen, GC; ... (24 authors) (Nature, 2013-06-13)
      DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin structure are implicated in the initiation ...