Browsing Scholarly Articles by Subject "Dacarbazine"

Hodgkin lymphoma treatment with ABVD in the US and the EU: neutropenia occurrence and impaired chemotherapy delivery.

Schwenkglenks, M; Pettengell, R; Szucs, TD; Culakova, E; Lyman, GH (J Hematol Oncol, 2010-08-19)

BACKGROUND: In newly diagnosed patients with Hodgkin lymphoma (HL) the effect of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD)-related neutropenia on chemotherapy delivery is poorly documented. The aim of this ...

Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.

Archer, GE; Bigner, DD; Choi, BD; Cui, X; Flores, C; Herndon, James Emmett II; Johnson, LA; ... (12 authors) (PLoS One, 2013)

Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with high grade glioma and is routinely used to treat melanoma brain metastases. A prominent side effect of TMZ is induction of profound lymphopenia, ...

Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma.

Bailey, L; Coan, A; Desjardins, A; Friedman, HS; Herndon, James Emmett II; Lipp, Eric S; Lou, E; ... (12 authors) (Cancer Med, 2013-04)

Patients with unresectable glioblastomas have a poor prognosis, with median survival of 6-10 months. We conducted a phase II trial of upfront 5-day temozolomide (TMZ) and bevacizumab (BV) in patients with newly diagnosed ...