Browsing Scholarly Articles by Subject "VACCINE DESIGN"

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Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.

Haynes, Barton; Wiehe, Kevin; Bradley, Todd; Williams, Wilton; Bonsignori, Mattia; Saunders, Kevin; Meyerhoff, R Ryan; ... (12 authors) (Cell host & microbe, 2018-06)

HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequeent ...