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    • Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. 

      Caron, MG; Chen, JK; Fralish, GB; Kelly, P; Lefkowitz, Robert J; Meloni, AR; Salahpour, A; ... (8 authors) (Mol Cell Biol, 2006-10)
      Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation ...