Now showing items 1-12 of 12

    • Constant mortality and fertility over age in Hydra. 

      Schaible, R; Scheuerlein, A; Dańko, MJ; Gampe, J; Martínez, DE; Vaupel, James Walton (Proc Natl Acad Sci U S A, 2015-12-22)
      Senescence, the increase in mortality and decline in fertility with age after maturity, was thought to be inevitable for all multicellular species capable of repeated breeding. Recent theoretical advances and compilations ...
    • Losses of expected lifetime in the United States and other developed countries: methods and empirical analyses. 

      Shkolnikov, VM; Andreev, EM; Zhang, Z; Oeppen, J; Vaupel, James Walton (Demography, 2011-02)
      Patterns of diversity in age at death are examined using e (†), a dispersion measure that equals the average expected lifetime lost at death. We apply two methods for decomposing differences in e (†). The first method estimates ...
    • Management of prostate cancer in older men: recommendations of a working group of the International Society of Geriatric Oncology. 

      Droz, JP; Balducci, L; Bolla, M; Emberton, M; Fitzpatrick, JM; Joniau, S; Kattan, MW; ... (13 authors) (BJU Int, 2010-08)
      Prostate cancer is the most prevalent cancer in men and predominantly affects older men (aged >or=70 years). The median age at diagnosis is 68 years; overall, two-thirds of prostate cancer-related deaths occur in men aged ...
    • [More people live to be very old and with a better functioning]. 

      Christensen, Kaare; Jeune, B; Andersen-Ranberg, K; Vaupel, James Walton (Ugeskr Laeger, 2013-10-07)
      Death rates for 80+-year-olds are now half of what they were after WWII. The chance of living past 90 years has gone up by roughly 30% per decade for people born in Denmark in 1895, 1905, and 1915 - and the later cohorts ...
    • Quantification of biological aging in young adults. 

      Belsky, Daniel W; Caspi, Avshalom; Cohen, Harvey Jay; Corcoran, DL; Danese, A; Harrington, Hona Lee; Houts, Renate M; ... (15 authors) (Proc Natl Acad Sci U S A, 2015-07-28)
      Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young ...
    • Research versus Rhetoric. 

      Vaupel, James Walton; Rau, R (Gerontology, 2013)
      Limited to 1,000 words, we address some serious technical mistakes and factual errors, as well as the misleading quotations in the section of Olshansky's and Carnes' article that attacks some of our joint research.
    • Rise, stagnation, and rise of Danish women's life expectancy. 

      Canudas-Romo, V; Christensen, Kaare; Jeune, B; Lenart, A; Lindahl-Jacobsen, R; Rau, R; Vaupel, James Walton (Proc Natl Acad Sci U S A, 2016-04-12)
      Health conditions change from year to year, with a general tendency in many countries for improvement. These conditions also change from one birth cohort to another: some generations suffer more adverse events in childhood, ...
    • Sex differences in health and mortality in Moscow and Denmark. 

      Christensen, Kaare; Oksuzyan, A; Shkolnikov, VM; Shkolnikova, Maria A; Vaupel, James Walton (Eur J Epidemiol, 2014-04)
      In high income countries females outlive men, although they generally report worse health, the so-called male-female health-survival paradox. Russia has one of the world's largest sex difference in life expectancy with a ...
    • Steep increase in best-practice cohort life expectancy. 

      Shkolnikov, VM; Jdanov, DA; Andreev, EM; Vaupel, James Walton (Popul Dev Rev, 2011)
      We analyze trends in best-practice life expectancy among female cohorts born from 1870 to 1950. Cohorts experience declining rather than constant death rates, and cohort life expectancy usually exceeds period life expectancy. ...
    • Survival differences among native-born and foreign-born older adults in the United States. 

      Dupre, Matthew Egan; Gu, D; Vaupel, James Walton (PLoS One, 2012)
      BACKGROUND: Studies show that the U.S. foreign-born population has lower mortality than the native-born population before age 65. Until recently, the lack of data prohibited reliable comparisons of U.S. mortality by nativity ...
    • The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span. 

      Akushevich, Igor; Arbeev, Konstantin; Kulminski, Alexander; Land, Kenneth C; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Phys Life Rev, 2012-06)
      A better understanding of processes and mechanisms linking human aging with changes in health status and survival requires methods capable of analyzing new data that take into account knowledge about these processes accumulated ...
    • Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study. 

      Arbeev, Konstantin; Culminskaya, IV; Kulminski, Alexander; Province, MA; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Rejuvenation Res, 2015-04)
      The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex. One complicating factor is genetic trade-off. Here we focused ...