Now showing items 1-10 of 1861
Association of Common Genetic Polymorphisms with Melanoma Patient IL-12p40 Blood Levels, Risk, and Outcomes
(JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015-09)
Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Setting objective thresholds for rare event detection in flow cytometry
(Journal of Immunological Methods, 2014-01-01)
The accurate identification of rare antigen-specific cytokine positive cells from peripheral blood mononuclear cells (PBMC) after antigenic stimulation in an intracellular staining (ICS) flow cytometry assay is challenging, ...
Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway.
(Proceedings of the National Academy of Sciences of the United States of America, 2011-02-07)
Hundreds of mammalian nuclear and cytoplasmic proteins are reversibly glycosylated by O-linked β-N-acetylglucosamine (O-GlcNAc) to regulate their function, localization, and stability. Despite its broad functional significance, ...
Bringing chemistry to life.
(Nature methods, 2011-07-28)
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
(Science (New York, N.Y.), 2005-02)
Most protein phosphatases have little intrinsic substrate specificity, making selective pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a screen for small molecules that protect ...
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
(Nature genetics, 2018-02)
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). We demonstrated that conditional ...
Preclinical and Coclinical Studies in Prostate Cancer.
(Cold Spring Harbor perspectives in medicine, 2018-04-02)
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage ...
Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
(The Journal of pathology, 2012-01)
Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the prostate and oestrogen receptor (ER) α is required to mediate this response. Previous studies utilizing tissue recombination with seminal ...
Sarcopenia: A Time for Action. An SCWD Position Paper.
(Journal of cachexia, sarcopenia and muscle, 2019-10)
The term sarcopenia was introduced in 1988. The original definition was a "muscle loss" of the appendicular muscle mass in the older people as measured by dual energy x-ray absorptiometry (DXA). In 2010, the definition was ...