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MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.
(Redox biology, 2019-01)
Negative Pressure Wound Therapy (NPWT), a widely used modality in the management of
surgical and trauma wounds, offers clear benefits over conventional wound healing
strategies. Despite the wide-ranging effects ascribed ...
Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
(The New England journal of medicine, 2017-06)
BACKGROUND:After a single-center trial and observational studies suggesting that early,
goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter
trials (ProCESS, ARISE, and ProMISe) showed no benefit. ...
Quality of Care and Outcomes for Patients With Stroke in the United States Admitted During the International Stroke Conference.
(Journal of the American Heart Association, 2018-11)
Background Patients presenting to hospitals during non-weekday hours experience worse
outcomes, often attributed to reduced staffing. The American Heart Association International
Stroke Conference ( ISC ) is well attended ...
Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.
(Lancet, 2016-02-13)
BACKGROUND: For children with sickle cell anaemia and high transcranial doppler (TCD)
flow velocities, regular blood transfusions can effectively prevent primary stroke,
but must be continued indefinitely. The efficacy of ...
Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial.
(Trials, 2015-04-30)
BACKGROUND: Despite the high prevalence and global impact of knee osteoarthritis (KOA),
current treatments are palliative. No disease modifying anti-osteoarthritic drug (DMOAD)
has been approved. We recently demonstrated ...
Catheter Ablation of Atrial Fibrillation in U.S. Community Practice--Results From Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).
(J Am Heart Assoc, 2015-05-21)
BACKGROUND: The characteristics of patients undergoing atrial fibrillation (AF) ablation
and subsequent outcomes in community practice are not well described. METHODS AND
RESULTS: Using the Outcomes Registry for Better Informed ...
Specialist and primary care physicians' views on barriers to adequate preparation of patients for renal replacement therapy: a qualitative study.
(BMC Nephrol, 2015-03-28)
BACKGROUND: Early preparation for renal replacement therapy (RRT) is recommended for
patients with advanced chronic kidney disease (CKD), yet many patients initiate RRT
urgently and/or are inadequately prepared. METHODS: ...
Teaching neuraxial anesthesia techniques for obstetric care in a Ghanaian referral hospital: achievements and obstacles.
(Anesth Analg, 2015-06)
Anesthesia providers in low-income countries may infrequently provide regional anesthesia
techniques for obstetrics due to insufficient training and supplies, limited manpower,
and a lack of perceived need. In 2007, Kybele, ...
Association Between Comorbidities and Outcomes in Heart Failure Patients With and Without an Implantable Cardioverter-Defibrillator for Primary Prevention.
(J Am Heart Assoc, 2015-08-06)
BACKGROUND: Implantable cardioverter-defibrillator (ICD) therapy is associated with
improved outcomes in patients with heart failure (HF), but whether this association
holds among older patients with multiple comorbid illnesses ...
The effect of gemfibrozil, niacin and cholestyramine combination therapy on metabolic syndrome in the Armed Forces Regression Study.
(Am J Med Sci, 2011-05)
INTRODUCTION: Metabolic syndrome is a powerful predictor of cardiovascular events
independent of overt diabetes. Dietary restriction and weight loss modify metabolic
syndrome components. This study addresses whether combination ...