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Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.
(Journal of experimental & clinical cancer research : CR, 2011-01-07)
SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ...